- Influence of phosphoramidites in copper-catalyzed conjugate borylation reaction
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Copper(I) has become the preferred metal to catalyze the β-boration of α,β-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites and phosphites, can be convenient alternative ligands to induce asymmetry in the enantioselective version of this reaction, particularly in the β-boration of α,β-unsaturated imines.
- Sole, Cristina,Bonet, Amadeu,De Vries, Andre H. M.,De Vries, Johannes G.,Lefort, Laurent,Gulyas, Henrik,Fernandez, Elena
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p. 7855 - 7861
(2013/01/16)
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- Rapid identification of a scalable catalyst for the asymmetric hydrogenation of a sterically demanding aryl enamide
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High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity.
- Lefort, Laurent,Boogers, Jeroen A. F.,Kuilman, Thijs,Vijn, Robert Jan,Janssen, John,Straatman, Harrie,De Vries, Johannes G.,De Vries, Andre H. M.
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supporting information; experimental part
p. 568 - 573
(2011/07/08)
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- Synthesis of Chiral Phosphorus Reagents and Their Catalytic Activity in Asymmetric Borane Reduction of N-Phenyl Imine of Acetophenone
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Eleven chiral trivalent or quatrivalent phosphorus reagents were synthesized starting from L-proline, D-camphor, (+)- or (-)-1,1'-binaphthalene-2,2'-diol, (-)-α-phenylethylamine, etc. and their application as catalysts in asymmetric borane reduction of N-
- Kangying, Li,Zhenghong, Zhou,Guofeng, Zhao,Chuchi, Tang
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p. 546 - 550
(2007/10/03)
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- Cyclophosphorylation of polyphenols by diamidoarylphosphites
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It was found that the cyclophosphorylation of polyphenols by diamidoarylphosphites proceeds via the rupture of only one P-N bond and one P-O bond, the second P-N bond remaining intact. It is supposed that the unusual lack of reactivity of the P-N bond is due to the spatial arrangement of the amido group with respect to the reaction site in phosphorylated intermediates 5.
- Maslennikova, Vera I.,Merkulov, Roman V.,Dyagileva, Maria V.,Vasyanina, Larisa K.,Lyssenko, Konstantin A.,Antipin, Mikhail Yu.,Weber, Dirk,Bauer, Ingmar,Habicher, Wolf D.,Nifantyev, Eduard E.
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p. 1753 - 1761
(2007/10/03)
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- New chiral phosphorus catalysts derived from (S)-binaphthol for highly enantioselective reduction of acetophenone by borane
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New chiral (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine 1 and its borane complex 3 were prepared from (S)-binaphthol and their use as catalysts in enantioselective borane reductions of prochiral acetophenone were investigated. Enantiomeri
- Ma, Margaret F. P.,Li, Kangying,Zhou, Zhenghong,Tang, Chuchi,Chan, Albert S. C.
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p. 3259 - 3261
(2007/10/03)
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