- Intramolecular Cooperative Reactions of 1,2-Bis(diazoketone)s. The First Syntheses of trans-Hydro-1H-2-inden-1-ones
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The intramolecular cooperative reactions of 1,2-bis(diazoketone)s initiated by the Wolff rearrangement of α-diazoketones have been investigated.Under thermal conditions, 1,2-bis(diazoketone)s are efficiently transformed into 2-cyclopenten-1-one derivatives with complete stereospecificity.Thus, a most extraordinary result is reported, that trans-hydro-2-inden-1-ones (1-3) were synthesized for the first time from trans-1,2-bis(diazoketone)s (5, 11, and 12), respectively.The unprecedented trans-hydroindenone structure was confirmed by X-ray analysis of 3 as well as 1H NMR analysis and was supported by ab initio molecular orbital calculations.The same reactions were also carried out under photochemical conditions and were applied to 1,3-bis(diazoketone)s, giving 2-cyclohexen-1-one derivatives.
- Nakatani, Kazuhiko,Takada, Kazunori,Isoe, Sachihiko
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p. 2466 - 2473
(2007/10/02)
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- Antimicrobial compositions
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Low-foaming antimicrobial concentrate and "use" composition comprising (a) an antimicrobial agent selected from the group consisting of monocarboxylic acids, dicarboxylic acids and mixtures thereof, (b) a solubilizer, (c) an acid capable of yielding a pH less than or equal to about 5.0 upon dilution of the concentrate to a use solution, and (d) a diluent. This composition provides effective storage stability and low-foaming sanitization when used in "in-place" processing lines such as dairies, breweries and other food processing facilities.
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