- CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS
-
The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.
- -
-
Paragraph 0356
(2019/07/13)
-
- NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS
-
The present invention discloses compounds according to Formula I: wherein R1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.
- -
-
Paragraph 0725-0726; 0727-0728
(2015/02/25)
-
- THIENO[2,3-C]PYRANS AS CFTR MODULATORS
-
The present invention discloses compounds according to Formula I: Wherein R is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.
- -
-
Paragraph 00221
(2015/02/25)
-
- Cyclic AMP-specific phosphodiesterase inhibitors
-
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
- -
-
-
- An Expedient Synthesis of Cyclopropanone Cyanohydrins
-
A practical and general synthesis of cyclopropanone cyanohydrins starting from readily available 1-hydroxycyclopropanecarboxylic acids is described.
- Hartmann, Willy
-
p. 272 - 274
(2007/10/02)
-