Process for preparing peptides and N-carbamoyl-protected peptides
The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables peptides to be synthesized simply and economically and the protective group to be separated carefully. The process comprises three reaction steps: 1. Preparation of N-carbamoyl amino acid or N-carbamoyl amino acid derivatives; 2. Formation of the peptide bond between the carbamoyl-protected electrophile and nucelophile; and 3. Separation of the carbamoyl-protective group.
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(2008/06/13)
A SUPERIOR SYNTHESIS OF ASPARTAME
The dipeptide sweetener aspartame has been prepared in high yield via the coupling of L-phenylalanine methyl ester and L-aspartic acid N-thiocarboxyanhydride.
Vinick, Fredic J.,Jung, Stanley
p. 1315 - 1318
(2007/10/02)
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