Highly efficient reduction of aldehydes with silanes in water catalyzed by silver
A highly efficient silver-catalyzed chemoselective method for the reduction of aldehydes to their corresponding alcohols in water was developed by using hydrosilanes as reducing agents. The ketones remained essentially inert under the same reaction conditions, thereby providing an additional synthetically useful chemoselectivity. Georg Thieme Verlag Stuttgart, New York.
Wake-promoting agents: Search for next generation modafinil: Part IV
In search of a next generation molecule to the novel wake promoting agent modafinil, a series of diphenyl ether derived wakefulness enhancing agents (in rat) was developed. From this work, racemic compound 16 was separated into its chiral enantiomers to p
Louvet, Philippe,Schweizer, Dominique,Gourdel, Marie-Edith,Riguet, Eric,Yue, Christoph,Marcy, Val R.,Lin, Yin Guo,Gruner, John,Lesur, Brigitte,Bacon, Edward R.,Chatterjee, Sankar
scheme or table
p. 949 - 951
(2012/10/08)
Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors
The p38 MAP kinase is a key enzyme in inflammatory diseases as it is involved in the biosynthesis of proinflammatory cytokines such as TNF-α and IL-1β. Small molecule p38 inhibitors suppress the production of these cytokines and therefore p38 is a promisi
Dorn, Angelika,Schattel, Verena,Laufer, Stefan
scheme or table
p. 3074 - 3077
(2010/07/18)
Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives
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Ong,Profitt,Spaulding,Wilker
p. 834 - 839
(2007/10/05)
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