- N, O - dimethyl - N - nitro-isourea preparation method
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The invention discloses a method for preparing N,O-dimethyl-N-nitroisourea by amination reaction, methylation reaction and nitration reaction. The equation is disclosed in the specification. The methyl urea obtained by the amination reaction and the monomethyl sulfate obtained by the methylation reaction can be directly used for the nitration reaction without purification. The cheap and accessible ammonia gas is used as the amination reagent in the amination reaction; in the nitration reaction, the sulfuric acid is used as a catalyst and a reaction solvent, thereby further lowering the raw material cost of the method; and the method has the advantages of mild technological conditions, wide raw material sources, lower production cost, high product quality and high content, and is easy to operate and suitable for industrial production.
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Paragraph 0021; 0022; 0023; 0024; 0025; 0026; 0027-0042
(2017/08/24)
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- A synthetic method of the dinotefuran (by machine translation)
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The invention discloses a method for synthesis of dinotefuran, to γ - butyrolactone as raw materials, by Aldol condensation, also the original two-step by the reaction of 3 - hydroxy methyl tetrahydrofuran, then by the Gabriel synthesis of 3 - tetrahydrofuran methyl amine, dimethyl carbonate (DMC) as methylation reagent with the urea synthesis O - methyl isourea, re-nitration synthetic O - methyl - N - nitro-isourea, then with the methylamine reaction synthesis of 1, 3 - dimethyl - 2 - nitro-isourea, final 3 - tetrahydrofuran methylamine with 1, 3 - dimethyl - 2 - nitro-isourea through SN2 Bimolecular nucleophilic substitution reaction, one-step synthesis of dinotefuran. The present invention uses non of dimethyl carbonate as the methylating reagent, the methylation reaction yield ≥ 95%, O - methyl isourea content ≥ 96%, the by-product is carbon dioxide and methanol, process and environmental protection, the overall yield of the dinotefuran ≥ 50%. Synthetic method of this invention to reduce the production cost at the same time, with three wastes, after treatment is simple, the advantages of the environment friendly, and is suitable for industrial production, bring about significant economic benefits. (by machine translation)
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Paragraph 0057; 0059; 0076; 0077; 0095; 0097
(2017/08/27)
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- IMPROVED METHOD FOR PRODUCING NITROISOUREA DERIVATIVE
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Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,
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Page/Page column 5
(2008/12/04)
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