- PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL
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The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.
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Page/Page column 69-73
(2019/10/01)
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- Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers
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Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.
- Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu
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p. 587 - 593
(2019/07/22)
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- Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation
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An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi
- Ganiek, Maximilian A.,Becker, Matthias R.,Berionni, Guillaume,Zipse, Hendrik,Knochel, Paul
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supporting information
p. 10280 - 10284
(2017/08/07)
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- PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE
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The invention relates toa pharmaceutical composition comprising a pyrazole-O-glucoside derivative selected from the group of compounds (1) to (29) according to claim 1 in combination with at least one second therapeutic agent which is suitable in the trea
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Page/Page column 46
(2008/12/07)
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- ACYCLIC IKUR INHIBITORS
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A compound of formula I wherein R1, R2, R3, R4 and R5 are described herein.
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Page/Page column 90
(2010/11/26)
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- METHODS FOR PREVENTING AND TREATING METABOLIC DISORDERS AND NEW PYRAZOLE-O-GLYCOSIDE DERIVATIVES
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The invention relates to methods for preventing or treating metabolic disorders, for improving glycemic control, for preventing progression from impaired glucose tolerance, insulin resistance and/or from metabolic syndrome to type 2 diabetes mellitus, for
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Page/Page column 32
(2010/11/25)
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- PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS
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This invention pertains to a method of inhibiting undesired animal cellular proliferation said method comprising contacting an animal cell with a compound of Formula 1 and all pharmaceutically acceptable, salts, N-oxides, hydrates, solvates, or geometric and stereoisomers thereof: Formula (I) wherein R1 is NR4 R5, N=CR19 R21 OR6, G1 or G2; or C1-C8 alkyl, C2-C8 alkenyl, each optionally substituted; A is O, S or NR7; R2 is cyano, NR8-N=CR9 R10 or NC(=O)R30; or a 5- or 6-membered heteroaromatic ring, each ring or ring system optionally substituted; R3 is H, halogen, cyano, C1-C6 alkyl; J is C1- C8 alkyl or phenyl, optionally substituted; and R4, R5, R6, R7, R8, R9, R10, R19, R21, R30, G1 and G2 are defined in the disclosure.
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Page/Page column 68-69
(2008/06/13)
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