- Synthesis of various ferrite (MFe2O4) nanoparticles and their application as efficient and magnetically separable catalyst for biginelli reaction
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Herein, we reports the application of various spinel ferrite nanoparticles, MFe2O4 (M = Co, Ni, Cu, Zn), as efficient catalyst for Biginelli reaction. All ferrite nanoparticles were synthesized using a novel aqueous solution based me
- Chandel, Madhurya,Ghosh, Barun Kumar,Moitra, Debabrata,Patra, Manoj Kumar,Vadera, Sampat Raj,Ghosh, Narendra Nath
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Read Online
- Synthesis of Chiral 3,4-Dihydropyrimidin-2(1H)-one Derivatives and Their Stereoselective Chlorination with Chlorine Dioxide
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Optically active derivatives of 3,4-dihydropyrimidin-2(1H)-one have been synthesized on the basis of myrtenal and methyl 2,3-O-isopropylidene-α-L-erythro-pentodialdo-1,4-furanoside in 45 and 50% yields, respectively, and subjected to stereoselective chlor
- Izmest’ev,Pestova,Rubtsova,Kutchin
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Read Online
- Synthesis of Glycoluril using Urea Phosphate
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Abstract: Glycolurils are building blocks for the synthesis of cucurbiturils that are important host materials for several applications. Glycolurils are prepared conveniently by the condensation of 1,2-diketones with urea using an acid as catalyst. Herein, we report a facile method of synthesis of various glycolurils using urea phosphate and 1,2-diketones.
- Karpagalakshmi, K.,Lakshminarayanan, P.,Prakash, R.,Ramalakshmi, S.,Selvapalam, N.,Usha, G.,Yang, C.
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p. 1988 - 1992
(2022/01/24)
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- Synthesis method of dihydropyrimidinone compound
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The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a
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Paragraph 0034-0036; 0040-0041; 0044; 0054-0058; 0060
(2021/05/19)
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- Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions
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An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq
- Li, Ningbo,Wang, Yijun,Liu, Feijun,Zhao, Xin,Xu, Xinhua,An, Quan,Yun, Keming
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- CoNiFe2O4@Silica-SO3H nanoparticles: New recyclable magnetic nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions
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A useful and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were achieved by one-pot cyclocondensation between substituted aryl aldehydes, diketone/ketoester, and urea/thiourea using magnetic CoNiFe2O4@Silica-
- Karimian, Azam,Rad, Masoud Saadati,Mahdavi, Elham
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p. 1702 - 1714
(2020/09/07)
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- Synthesis and characterization of nano acid catalyst derived from rice husk silica and its application for the synthesis of 3,4-dihydropyrimidinones/thiones compounds
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In the present work, the extraction of silica nanoparticles from the rice husk followed by the modification using an acidic ionic liquid containing imidazolium butyl sulfonic acid through a sol-gel method (RH@[SiPrImBuSO3H]Cl) has been investig
- Davarpanah, Jamal,Sayahi, Mohammad Hosein,Ghahremani, Mahboubeh,Karkhoei, Sahar
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p. 546 - 555
(2019/01/21)
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- Highly Efficient Synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones (DHPMs) Catalyzed by Hf(OTf)4: Mechanistic insights into reaction pathways under metal Lewis acid catalysis and solvent-free conditions
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In our studies on the catalytic activity of Group IVB transition metal Lewis acids, Hf(OTf)4 was identified as a highly potent catalyst for”one-pot, three-component” Biginelli reaction. More importantly, it was found that solvent-free conditions, in contrast to solvent-based conditions, could dramatically promote the Hf(OTf)4-catalyzed formation of 3,4-dihydro-pyrimidin-2-(1H)-ones. To provide a mechanistic explanation, we closely examined the catalytic effects of Hf(OTf)4 on all three potential reaction pathways in both “sequential bimolecular condensations” and “one-pot, three-component” manners. The experimental results showed that the synergistic effects of solvent-free conditions and Hf(OTf)4 catalysis not only drastically accelerate Biginelli reaction by enhancing the imine route and activating the enamine route but also avoid the formation of Knoevenagel adduct, which may lead to an undesired byproduct. In addition, 1H-MMR tracing of the H-D exchange reaction of methyl acetoacetate in MeOH-d4 indicated that Hf(IV) cation may significantly accelerate ketone-enol tautomerization and activate the β-ketone moiety, thereby contributing to the overall reaction rate.
- Kong, Rui,Han, Shuai-Bo,Wei, Jing-Ying,Peng, Xiao-Chong,Xie, Zhen-Biao,Gong, Shan-Shan,Sun, Qi
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- Preparation method and application of novel ionic salicylaldehyde Schiff base zirconium complex (by machine translation)
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The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic salicylaldehyde Schiff base zirconium complex. The cationic part is formed by coordination of zi
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Paragraph 0082-0083
(2019/11/20)
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- SnO2 nanoparticles: An efficient reusable heterogeneous catalyst for synthesis of 3,4-dihydropyrimidinones under solvent-free conditions
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Some 3,4-dihydropyrimidine derivatives have been synthesized from the reaction of divergent aldehydes with acetylacetone and urea/thiourea using nano tin oxide nanoparticles under solvent-free condition. The nanoparticle catalyst used in this synthesis is
- Priyadharsini,Chitra
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p. 243 - 248
(2018/09/14)
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- Efficient Catalytic Synthesis of 3,4-Dihydropyrimidin-2-ones/thiones via Little Acidic Ionic Liquid Combined with Rapid Heating Ways
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Catalytic synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was efficiently promoted by as little as 2.5?mol% of Br?nsted acidic ionic liquid [(CH2)3SO3HMIM]HSO4 catalyst loading via rapid heating ways. Inter
- Zhang, Guo-Ping,Tian, Da-Yu,Shi, Wang-Ming
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p. 2522 - 2531
(2018/09/29)
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- Cu(II) immobilized on mesoporous organosilica as an efficient and reusable nanocatalyst for one-pot Biginelli reaction under solvent-free conditions
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Cu(II) immobilized on mesoporous organosilica nanoparticles (Cu2+@MSNs-(CO2 ?)2) has been synthesized, as a inorganic–organic nanohybrid catalyst, through a post-grafting approach. Its characterization is carrie
- Nasresfahani, Zahra,Kassaee, Mohammad Zaman
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- Nebivolol nanoparticles: A first catalytic use in Biginelli and Biginelli-like reactions
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Herein, we report the catalytic activity of nebivolol nanoparticles a novel organocatalyst for the synthesis of DHPMs and DHPM-5-carboxamides. The nanoparticles are confirmed by DSC, TEM, AFM, and IR spectroscopy. The catalyst can be readily recovered and
- Khaskel, Anamika,Barman, Pranjit,Maiti, Subir Kumar,Jana, Utpal
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p. 1021 - 1025
(2018/11/24)
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- (C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction
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A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to
- Zhang, Xiang,Gu, Xiaoyu,Gao, Yuhua,Nie, Shipeng,Lu, Hongfei
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- BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives
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BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz
- Shirini, Farhad,Lati, Monireh Pourghasemi
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- Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition
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A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high
- Mohammadian, Narges,Akhlaghinia, Batool
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p. 3325 - 3347
(2017/04/21)
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- Microwave promoted Y(NO3)3·6H2O catalyzed Biginelli synthesis of dihydropyrimidin-2-ones
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Biginelli synthesis of 3,4-dihydropyrimidinones from aldehydes, β-keto ester and urea using yttrium nitrate hexahydrate, as an efficient catalyst are demonstrated under microwave condition. This method offers significant advantages, such as high yields, s
- Khan,Mitra,Mondal
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p. 529 - 534
(2017/02/19)
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- Cu-EDTA-modified APTMS-Fe3O4@SiO2 core-shell nanocatalyst: A novel magnetic recoverable catalyst for the Biginelli reaction
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A novel copper-ethylenediamine tetracarboxylate modified core-shell magnetic catalyst is introduced. The prepared catalyst was fully characterized by various spectroscopic analyses such as XRD, SEM, FT-IR, EDX, ICP, and CHNOS. After characterization, its
- Sheykhan, Mehdi,Yahyazadeh, Asieh,Rahemizadeh, Zahra
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p. 34553 - 34563
(2016/05/09)
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- PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions
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A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting
- Dalil Heirati, Seyedeh Zahra,Shirini, Farhad,Shojaei, Abdollah Fallah
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p. 67072 - 67085
(2016/07/30)
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- Potential antitumoral 3,4-dihydropyrimidin-2-(1: H)-ones: synthesis, in vitro biological evaluation and QSAR studies
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The search for novel anticancer agents with higher selectivity and lower toxicity remains a priority. This work aimed to design more potent and selective anticancer molecules among the class of 3,4-dihydropyrimidin-2-(1H)-ones. Thus, a series of molecules
- Matias, Mariana,Campos, Gon?alo,Santos, Adriana O.,Falc?o, Amílcar,Silvestre, Samuel,Alves, Gilberto
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p. 84943 - 84958
(2016/10/06)
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- Synthesis of a BiFeO3 nanowire-reduced graphene oxide based magnetically separable nanocatalyst and its versatile catalytic activity towards multiple organic reactions
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Herein, we report for the first time synthesis of a BiFeO3 nanowire-reduced graphene oxide nanocatalyst (BFO-RGO) using a hydrothermal method. The BFO-RGO nanocatalyst exhibited excellent catalytic activity towards Biginelli reaction, Click rea
- Moitra, Debabrata,Ghosh, Barun Kumar,Chandel, Madhurya,Ghosh, Narendra Nath
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p. 97941 - 97952
(2016/11/02)
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- Synthesizing method for 3,4-dihydropyrimidinone derivative
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The invention discloses a synthesizing method for a 3,4-dihydropyrimidinone derivative.The synthesizing method comprises the specific steps that (C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 serves as a catalyst, ethyl alcohol serves as a solvent, a reaction i
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Paragraph 0060; 0061; 0062; 0063; 0064
(2016/10/24)
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- Polymer-supported benzimidazolium based ionic liquid: An efficient and reusable Br?nsted acid catalyst for Biginelli reaction
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A polymer-supported benzimidazolium based ionic liquid (PSBIL) was synthesized by reaction of poly(vinylbenzyl chloride) and benzimidazole followed by ring opening of 1,4-butane sultone and acidification with sulphuric acid. The resulting Br?nsted acid he
- Khiratkar, Avinash Ganesh,Muskawar, Prashant Narayan,Bhagat, Pundlik Rambhau
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p. 105087 - 105093
(2016/11/18)
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- USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS
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The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.
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Paragraph 0648
(2016/01/25)
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- Solvent-Free Ball-Milling Biginelli Reaction by Subcomponent Synthesis
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We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof-of-concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed un
- Sahoo, Prasit Kumar,Bose, Anima,Mal, Prasenjit
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supporting information
p. 6994 - 6998
(2015/11/16)
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- B(C6F5)3 catalyzed one-pot three-component Biginelli reaction: An efficient and environmentally benign protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
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Tris(pentafluorophenyl)borane catalyzed, one-pot, simple, efficient and environmentally benign protocol for the synthesis of dihydropyrimidinones/thiones via Biginelli reaction has been described. The main highlights of the present protocol is low catalys
- Prajapti, Santosh Kumar,Gupta, Keshav Kumar,Babu, Bathini Nagendra
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p. 1047 - 1052
(2015/09/07)
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- Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids under Solvent-Free Conditions
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An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found t
- Fu, Renzhong,Yang, Yang,Lai, Wenchen,Ma, Yongfeng,Chen, Zhikai,Zhou, Jian,Chai, Wen,Wang, Quan,Yuan, Rongxin
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supporting information
p. 477 - 487
(2015/10/29)
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- Air-stable zirconocene bis(perfluorobutanesulfonate) as a highly efficient catalyst for synthesis of N-heterocyclic compounds
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Zirconocene bis(perfluorobutanesulfonate) is air- and water-stable and proved to be ionic on basis of conductivity measurements. It exhibits high catalytic efficiency for the synthesis of N-heterocyclic compounds under solvent-free condition, such as benzimidazoles, benzodiazepines, dihydropyrimidinones and dihydropyridines under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles. This catalytic system affords a simple and efficient approach for the synthesis of N-heterocyclic compounds.
- Wang, Jinying,Li, Ningbo,Qiu, Renhua,Zhang, Xiaohong,Xu, Xinhua,Yin, Shuang-Feng
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- Fe3O4@Silica sulfuric acid core-shell composite as a novel nanomagnetic solid acid: Synthesis, characterization and application as an efficient and reusable catalyst for one-pot synthesis of 3,4-dihydropyrimidinones/thiones under sol
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Abstract A simple and convenient method was used to prepare Fe3O4@Silica sulfuric acid core-shell composite using Fe3O4 spheres as the core and silica sulfuric acid nanoparticles as the shell. Magnetite nanopart
- Kiasat, Ali Reza,Davarpanah, Jamal
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p. 2991 - 3001
(2015/04/27)
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- Synthesis of 3,4-dihydropyrimidin-2(1H)-one via one-pot Biginelli reaction under solvent-free conditions
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Three novel heteropolyanion-based acidic ionic liquids, [TMAPS]H2PMo12O40, [TEAPS]H2PMo12O40, and [TBAPS]H2PMo12O40, were used as efficient catalysts for th
- Peng, Huan,Hu, Yulin,Xing, Rong,Fang, Dong
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p. 2053 - 2058
(2015/11/24)
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- Immobilization of phosphomolybdic acid nanoparticles on imidazole functionalized Fe3O4@SiO2: A novel and reusable nanocatalyst for one-pot synthesis of Biginelli-type 3,4-dihydro-pyrimidine-2-(1H)-ones/thiones under solven
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This article introduces Fe3O4@SiO2-imid-H3PMo12O40 nanoparticles as heterogenic catalyst for the synthesis of 3,4-dihydropyrimidinones under solvent-free condition. This reaction proceeds t
- Javidi, Jaber,Esmaeilpour, Mohsen,Dodeji, Fatemeh Nowroozi
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p. 308 - 315
(2015/02/03)
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- β-Cyclodextrin-propyl sulfonic acid: A new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidones via Biginelli reaction
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β-Cyclodextrin-propyl sulfonic acid (β-CD-PSA) is reported as a new and eco-friendly catalyst for the synthesis of 3,4-dihydropyrimidinones from one-pot multi-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under so
- Gong, Kai,Wang, Hualan,Wang, Shuxin,Ren, Xiaoxue
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p. 4830 - 4834
(2015/07/27)
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- Phthalimide-N-sulfonic acid: a new and efficient organocatalyst for the Biginelli reaction under solvent-free conditions
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Abstract Phthalimide-N-sulfonic acid (PISA) was straightforwardly synthesized via addition of chlorosulfonic acid to a solution of potassium phthalimide in dry dichloromethane. This reagent is found to be an efficient solid acidic catalyst in the Biginell
- Kiyani, Hamzeh,Ghiasi, Maryam
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p. 6635 - 6648
(2015/08/18)
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- Boehmite nanoparticle catalyst for the one-pot multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones under solvent-free conditions
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A simple, green, and efficient synthesis protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using boehmite nanoparticles as catalyst was developed. It did not use any toxic metal catalysts or corrosive acidic reagents. The method gave good to excellent yields and has short reaction time, operational simplicity, and a recyclable catalyst.
- Keivanloo, Ali,Mirzaee, Mahdi,Bakherad, Mohammad,Soozani, Atena
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p. 362 - 367
(2014/04/03)
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- N-Sulfonic acid poly(4-vinylpyridinium) chloride as a highly efficient and reusable catalyst for the Biginelli reaction
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A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and -thiones is described using N-sulfonic acid poly(4-vinylpyridinium) chloride (NSPVPC) as a heterogeneous and efficient catalyst under solvent-free conditions
- Shirini, Frahad,Abedini, Masoumeh,Pourhasan-Kisomi, Reyhaneh
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p. 111 - 114
(2014/02/14)
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- Bronsted acidic ionic liquid based magnetic nanoparticles: A new promoter for the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
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The Bronsted acidic ionic liquid 1-methyl-3-(3- trimethoxysilylpropyl) imidazolium hydrogen sulfate was immobilized on magnetic Fe3O4 nanoparticles (MNPs-IL-HSO4). The properties of the magnetic nanocatalyst were character
- Safari, Javad,Zarnegar, Zohre
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p. 358 - 365
(2014/01/06)
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- Sulphated silica tungstic acid as a highly efficient and recyclable solid acid catalyst for the synthesis of tetrahydropyrimidines and dihydropyrimidines
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For the first time sulphated silica tungstic acid (SSTA) has been synthesized and used as an acidic catalyst in organic synthesis. The catalyst was prepared by a simple method based on the reaction of silica with SOCl 2 followed by addition of
- Ahmed, Nayeem,Siddiqui, Zeba N.
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- Efficient and green catalytic synthesis of dihydropyrimidinone (thione) derivatives using cobalt nitrate in solvent-free conditions
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A series of 3,4-dihydropyrimidin-2(1H)-one(thione) derivatives was synthesized using Co(NO3)2.6H2O in solvent-free condition. Avoiding organic solvents during the chemical reactions leading to an economic approach is effective. The reaction is characteriz
- Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Aghel-Mirrezaee, Maryam,Kashi, Hassan
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p. 2311 - 2314
(2014/07/22)
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- Synthesis of polyacrylonitrile fiber-supported poly(ammonium methanesulfonate)s as active and recyclable heterogeneous br?nsted acid catalysts
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A new polyacrylonitrile fiber-supported Br?nsted acid catalyst has been developed and verified to efficiently (high yield, 10 cycles) mediate Biginelli reactions in ethanol, Pechmann condensations in toluene, Friedel-Crafts alkylations of indoles in water and conversion of fructose in dimethyl sulfoxide (DMSO) and mixed-aqueous system.
- Shi, Xian-Lei,Xing, Xiaoli,Lin, Huikun,Zhang, Wenqin
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supporting information
p. 2349 - 2354
(2014/07/21)
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- Grindstone chemistry: A highly efficient and green method for synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by l-tyrosine as an organocatalyst: A combined experimental and DFT study
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A single step, mild, environmentally friendly green method has been developed for the synthesis of physiologically active 3,4-dihydropyrimidin-2- (1H)-ones employing l-tyrosine as catalyst under solvent-free conditions at room temperature via grinding. Th
- Khaskel, Anamika,Gogoi, Prasanta,Barman, Pranjit,Bandyopadhyay, Biman
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p. 35559 - 35567
(2014/11/07)
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- One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalysed by Cupric Acetate under Solvent-free Conditions
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A solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones from aromatic aldehydes, β-keto ester/acetyl acetone and urea catalysed by cupric acetate under thermal condition is reported as a simple and an efficient protocol. Compared with classical Bigine
- Kathing, Chingrishon,Rani, Jims World Star,Singh, Nongthombam Geetmani,Tumtin, Shokip,Nongrum, Ridaphun,Nongkhlaw, Rishanlang
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p. 1254 - 1258
(2016/02/19)
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- The biginelli reaction with an imidazolium-tagged recyclable iron catalyst: Kinetics, mechanism, and antitumoral activity
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The present work describes the synthesis, characterization, and application of a new ion-tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive performance. High yields have been achieved when the reaction was carried ou
- Ramos, Luciana M.,Guido, Bruna C.,Nobrega, Catharine C.,Corrêa, José R.,Silva, Rafael G.,De Oliveira, Heibbe C. B.,Gomes, Alexandre F.,Gozzo, Fábio C.,Neto, Brenno A. D.
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supporting information
p. 4156 - 4168
(2013/05/08)
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- Ionic liquid effect over the biginelli reaction under homogeneous and heterogeneous catalysis
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Bronsted and Lewis acid catalysts with ionic tags under homogeneous and heterogeneous conditions have been tested to perform the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one (DHPMs). Metal-containing ionic liquids were evaluated as the catalysts
- Alvim, Haline G. O.,De Lima, Tatiani B.,De Oliveira, Heibbe C. B.,Gozzo, Fabio C.,De MacEdo, Julio L.,Abdelnur, Patricia V.,Silva, Wender A.,Neto, Brenno A. D.
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p. 1420 - 1430
(2013/07/26)
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- One-pot synthesis of 3,4-dihydro-2(H)-pyrimidinones catalyzed by reusable acidic choline-based ionic liquids
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A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO4] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract: The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO4] > [Choline] [HSO4] > [DMEA][H 2PO4] > [Choline] [H2PO4][Figure not available: see fulltext.].
- Zhu, Anlian,Li, Qianqian,Li, Lingjun,Wang, Jianji
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p. 463 - 468
(2013/08/23)
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- Biginelli reaction on Fe3O4-MWCNT nanocomposite: Excellent reactivity and facile recyclability of the catalyst combined with ultrasound irradiation
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A highly efficient and improved synthetic methodology for the preparation of dihydropyrimidinone derivatives using β-dicarbonyl compounds, urea/thiourea and aromatic aldehydes using Fe3O4-MWCNT as a nanocatalyst under ultrasound irra
- Safari, Javad,Zarnegar, Zohre
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p. 17962 - 17967
(2013/10/01)
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- Ultrasound-mediated synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (or Thiones) with NaHSO4·H 2O
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A fast and efficient Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)- ones (or thiones) by the reaction of aromatic aldehydes, β-dicarbonyls, and urea/thiourea using NaHSO4·H2O/ultrasound system is presented. The reactions were ca
- Dilmaghani, Karim Akbari,Zeynizadeh, Behzad,Amirpoor, Maryam
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p. 1634 - 1642
(2013/10/21)
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- Vanadatesulfuric acid: A novel, recyclable, and heterogeneous catalyst for the one-pot synthesis of dihydropyrimidinones and dihydropyrimidinthiones under solvent-free conditions
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Vanadatesulfuric acid (VSA), as a novel and heterogeneous catalyst, was used for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) using an aldehyde, urea, or thiourea and an acyclic β-dicarbonyl compound under solvent-free conditions. V
- Nasr-Esfahani, Masoud,Abdizadeh, Tooba
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p. 596 - 608
(2013/07/25)
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- Imidazole functionalized magnetic Fe3O4 nanoparticles as a novel heterogeneous and efficient catalyst for synthesis of dihydropyrimidinones by Biginelli reaction
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Dihydropyrimidinone derivatives were synthesized in moderate to high yields in one-pot three-component condensation reactions from the corresponding aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of catalytic amounts of imidazole functional
- Nazari, Simin,Saadat, Shervin,Fard, Pegah Kazemian,Gorjizadeh, Maryam,Nezhad, Eshagh Rezaee,Afshari, Mozhgan
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p. 1877 - 1882
(2014/01/06)
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- Structure based virtual screening-driven identification of monastrol as a potent urease inhibitor
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Virtual screening uses computer based methods to discover new ligands on the basis of biological structures. Among all virtual screening methods structure based docking has received considerable attention. In an attempt to identify new ligands as urease i
- Rashid, Umer,Batool, Iram,Wadood, Abdul,Khan, Ajmal,Ul-Haq, Zaheer,Chaudhary, Muhammad Iqbal,Ansari, Farzana Latif
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- Synthesis of novel benzothiazolium ionic liquids and their catalytic performance in biginelli reaction
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Two new ionic liquids based on benzothiazolium cation were synthesized in satisfactory yields by using a modified two-step one-pot method. Then these ionic liquids were used as effective and environmentally friendly catalysts for the synthesis of 3,4-dihy
- Liu, Jiabing,Song, Hang,Luo, Wenfeng,Hui, Liwei,Yao, Shun
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p. 431 - 436
(2013/07/27)
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