- SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
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The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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- Nuclear Synthons: Mesyltriflone as an Olefin Polyanion Equivalent
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Mesyltriflone (CF3SO2CH2SO2CH3) is developed as a nuclear synthon reagent capable first of multiple constructions such as alkylations then of Ramberg-Baecklund elimination to a substituted olefin.The alkylations are clean and regiospecific, often amenable to one-pot operation, and in most cases the elimination is smooth.A variety of examples is presented to establish the scope of the method, and the mechanism and stereochemistry are discussed.
- Hendrickson, James B.,Boudreaux, Gerald J.,Palumbo, Paul S.
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p. 2358 - 2366
(2007/10/02)
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- Regioselective Reaction of Singlet Oxygen with α,β-Unsaturated Esters
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The reaction of singlet oxygen with α,β-unsaturated esters shows a general preference for hydrogen abstraction on the alkyl group geminal to the ester.
- Orfanopoulos, Michael,Foote, Christopher S.
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p. 5991 - 5994
(2007/10/02)
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- Polarized Ketene Dithioacetals. Part 42. Studies on the Reactions of Alkyl and Aryl Grignard Reagents with α-Oxoketene Dithioacetals
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The oxoketene dithioacetals (2a-k) derived from a variety of cyclic and acyclic active methylene ketones undergo 1,2-addition with methylmagnesium iodide to give the alcohol acetals (3a-k) which, on subsequent boron trifluoride-ether catalysed methanolysi
- Singh, Gurdeep,Purkayastha, Makhan L.,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
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p. 1289 - 1294
(2007/10/02)
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