- Fe-S Catalyst Generated in Situ from Fe(III)- And S3?--Promoted Aerobic Oxidation of Terminal Alkenes
-
An iron-sulfur complex formed by the simple mixture of FeCl3 with S3?- generated in situ from K2S is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atmosphere of O2 (balloon) and could proceed on a gram scale, expanding the application of S3?- in organic synthesis. This study also encourages us to explore the application of an Fe-S catalyst in organic reactions.
- Ai, Jing-Jing,Huang, Cheng-Mi,Li, Jian,Liu, Bei-Bei,Rao, Weidong,Wang, Fei,Wang, Shun-Yi
-
supporting information
p. 4705 - 4709
(2021/06/28)
-
- Photo-induced oxidative cleavage of C-C double bonds for the synthesis of biaryl methanoneviaCeCl3catalysis
-
A Ce-catalyzed strategy is developed to produce biaryl methanonesviaphotooxidative cleavage of C-C double bonds at room temperature. This reaction is performed under air and demonstrates high activity as well as functional group tolerance. A synergistic Ce/ROH catalytic mechanism is also proposed based on the experimental observations. This protocol should be the first successful Ce-catalyzed photooxidation reaction of olefins with air as the oxidant, which would provide inspiration for the development of novel Ce-catalyzed photochemical synthesis processes.
- Xie, Pan,Xue, Cheng,Du, Dongdong,Shi, SanShan
-
supporting information
p. 6781 - 6785
(2021/08/20)
-
- Decatungstate-mediated solar photooxidative cleavage of CC bonds using air as an oxidant in water
-
With the increasing attention for green chemistry and sustainable development, there has been much interest in searching for greener methods and sources in organic synthesis. However, toxic additives or solvents are inevitably involved in most organic transformations. Herein, we first report the combination of direct utilization of solar energy, air as the oxidant and water as the solvent for the selective cleavage of CC double bonds in aryl olefins. Various α-methyl styrenes, diaryl alkenes as well as terminal styrenes are well tolerated in this green and sustainable strategy and furnished the desired carbonyl products in satisfactory yields. Like heterogeneous catalysis, this homogeneous catalytic system could also be reused and it retains good activity even after repeating three times. Mechanism investigations indicated that both O2- and 1O2 were involved in the reaction. Based on these results, two possible mechanisms, including the electron transfer pathway and the energy transfer pathway, were proposed.
- Du, Dongdong,Luo, Junfei,Shi, Sanshan,Xie, Pan,Xue, Cheng
-
p. 5936 - 5943
(2021/08/23)
-
- A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for aerobic oxidation of alcohols
-
A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for the aerobic oxidation of alcohols has been developed for the first time, and the photoredox aerobic oxidation of secondary and primary alcohols provided the corresponding ketones and carboxylic acids, respectively, in high to excellent yields.
- Zhu, Xianjin,Liu, Can,Liu, Yong,Yang, Haijun,Fu, Hua
-
p. 12443 - 12446
(2020/10/30)
-
- Preparation method of aromatic ketone
-
The invention discloses a preparation method of aromatic ketone. Under the effects of a palladium catalyst and a nitrogen-containing ligand, nitrile compounds and arylsulfonylhydrazide take desulfurization addition reaction in an organic solvent; after the reaction is completed, post treatment is performed to obtain aromatic ketone. The reaction is applicable to aromatic nitrile compounds, and isalso applicable to aliphatic nitrile compounds; the reaction realizes the wide substrate applicability and functional group tolerance; the potential application value is realized in the aspect of aryl-carbonyl building.
- -
-
Paragraph 0046; 0047; 0048; 0050
(2018/09/11)
-
- Method for preparing aromatic ketone in aqueous phase
-
The invention discloses a method for preparing aromatic ketone in an aqueous phase, comprising the following steps: enabling aryl formyl potassium formate and aryl potassium fluoborate to generate decarboxylation acylation reaction in water under the actions of a silver catalyst and an oxidizing agent, and performing treatment after reaction is ended to obtain the disclosed aromatic ketone. According to the preparation method, the silver catalyst replaces a noble metal catalyst, water is taken as a solvent, an aromatic ketone product is obtained with relatively high yield, the adopted catalystis low in cost and easy to obtain, reaction conditions are mild, and meanwhile, the product is good in university, and therefore, the method has good application potential.
- -
-
Paragraph 0042-0045
(2018/04/26)
-
- Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles
-
A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.
- Meng, Mengting,Yang, Liangfeng,Cheng, Kai,Qi, Chenze
-
p. 3275 - 3284
(2018/03/25)
-
- A kind of alkali to promote self-oxidation of diaryl alkane preparation diarylketones method (by machine translation)
-
The invention discloses a kind of alkali to promote self-oxidation of diaryl alkane preparation diarylketones method. The method is that the diaryl paraffins compound is dissolved in an organic solvent in the drying of, the addition of a base, in the 25 - 80o C reaction under air or oxygen atmosphere for 0.5 - 5 hours, to obtain diarylketones; said two aryl paraffins compound and alkali molar ratio of 1:1 - 1:3. The method overcomes the need in the prior art strong acid or expensive metal reagent or a strong oxidizing agent and the like, has the following advantages: 1) to oxygen as the oxidizing agent, avoids the use of strong or expensive chemical oxidizing agent; 2) transition metal-free catalyst, avoids the heavy metal ion in the product; 3) the process is simple, low cost, wide range of the substrate, friendly to the environment. The synthesis method disclosed in this invention in the preparation of diarylketones industrialization of the play an important role in the production. (by machine translation)
- -
-
Paragraph 0019
(2017/08/28)
-
- Ag(i)/persulfate-catalyzed decarboxylative coupling of α-oxocarboxylates with organotrifluoroborates in water under room temperature
-
The decarboxylative coupling reaction of α-oxocarboxylates and organotrifluoroborates was carried out smoothly in the presence of catalytic AgNO3 using K2S2O8 as oxidant to generate diarylketone products in high
- Chang, Sheng,Wang, Jian Feng,Dong, Lin Lin,Wang, Dan,Feng, Bo,Shi, Yuan Tai
-
p. 51928 - 51934
(2017/11/22)
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- P -Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis
-
p-Selective (sp2)-C-H functionalization of electron rich arenes has been achieved for acylation and alkylation reactions, respectively, with acyl/alkylselenides by organic photoredox catalysis involving an interesting mechanistic pathway.
- Pandey, Ganesh,Tiwari, Sandip Kumar,Singh, Bhawana,Vanka, Kumar,Jain, Shailja
-
p. 12337 - 12340
(2017/11/20)
-
- T-BuONa-Mediated Transition-Metal-Free Autoxidation of Diarylmethanes to Ketones
-
Autoxidative sp3 C-H transformation of diarylmethanes has been demonstrated using O2-mediation by t-BuONa. This protocol enables an alternative route for the access to diaryl ketones from benzyl derivatives in good to excellent yields under mild reaction conditions, without transition metal catalysts or additional chemical oxidants.
- Li, Jiang-Sheng,Yang, Fan,Yang, Qian,Li, Zhi-Wei,Chen, Guo-Qin,Da, Yu-Dong,Huang, Peng-Mian,Chen, Chao,Zhang, Yuefei,Huang, Ling-Zhi
-
p. 994 - 998
(2017/05/10)
-
- Method for preparing diaryl ketone from aryl sulfonate
-
The invention discloses a method for preparing diaryl ketone from aryl sulfonate. The method includes following steps: in the presence of a catalyst and carbon monoxide, allowing aryl sulfonate and aryl boronic acid to react in an organic solvent; after reaction is finished, performing aftertreatment to obtain diaryl ketone. Aryl sufonate is adopted as an electrophilic reagent for Suzuki cross carbonylation coupling reaction, diaryl ketone is directly synthesized through carbon monoxide, aryl sulfonate and aryl boronic acid, reaction conditions are milk, functional groups are high in tolerance, a substrate is cheap and easy to get, and diaryl ketone can be prepared with high yield.
- -
-
Paragraph 0055; 0056
(2017/01/12)
-
- Carbonylative coupling of aryl tosylates/triflates with arylboronic acids under CO atmosphere
-
The carbonylative Suzuki-Miyaura reaction between aryl tosylates/triflates with arylboronic acid is herein reported, using base-free conditions and a balloon pressure of carbon monoxide. Under these conditions, unsymmetrical biaryl ketones were obtained in modest to excellent yields. This method was adapted to the synthesis of oxybenzone and ketoprofen in good yields under mild conditions.
- Hao, Cheng Yi,Wang, Dan,Li, Ya Wei,Dong, Lin Lin,Jin, Ying,Zhang, Xiu Rong,Zhu, He Yun,Chang, Sheng
-
p. 86502 - 86509
(2016/09/23)
-
- Carbonylative Hiyama coupling of aryl halides with arylsilanes under balloon pressure of CO
-
An efficient protocol has been developed for the carbonylative Hiyama coupling of aryl halides using the cesium fluoride as a promoter by palladium-catalyzed in NMP. This protocol was applied to a wide variety of functionalized and hindered aryl iodides and bromides with arylsilanes, to afford the desired biaryl ketones in good to excellent yields.
- Chang, Sheng,Jin, Ying,Zhang, Xiu Rong,Sun, Yong Bing
-
supporting information
p. 2017 - 2020
(2016/04/26)
-
- Nickel N-heterocyclic carbene-catalyzed cross-coupling reaction of aryl aldehydes with organozinc reagents to produce aryl ketones
-
The transformation of aromatic aldehydes into aryl ketones by nickel-catalyzed cross-coupling has been developed. This transformation represents an efficient and attractive synthetic utilization of organozinc reagents. The reaction provides a mild, practical method toward the synthesis of aryl ketones which are versatile intermediates and building blocks in organic synthesis.
- Jin, Cheng,Gu, Lijun,Yuan, Minglong
-
p. 4341 - 4345
(2015/09/01)
-
- Nickel N-heterocyclic carbene catalyzed C-C bond formation: A new route to aryl ketones
-
A novel nickel N-heterocyclic carbene catalyzed cross-coupling reaction of aryl aldehydes with boronic esters for the synthesis of aryl ketones was developed. This reaction provides a mild, practical method toward aryl ketones, which are versatile intermediates and building blocks in organic synthesis.
- Gu, Li-Jun,Jin, Cheng,Zhang, Hong-Tao
-
supporting information
p. 8741 - 8744
(2015/06/08)
-
- Copper-catalyzed aerobic synthesis of bisaryl ketones from alkynes via the cleavage of C-C triple bonds
-
A novel copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkynes via the cleavage of C-C triple bonds is reported. This reaction is a new transformation of 1,2-diarylalkynes into bisaryl ketones.
- Gu, Lijun,Zhang, Hongtao
-
p. 690 - 693
(2015/02/02)
-
- Efficient synthetic route to bisaryl ketones via copper-catalyzed C-C triple bonds cleavage
-
An efficient copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkynes via C-C triple bonds cleavage has been demonstrated. The aniline compounds were found to be crucial in our conditions and a plausible mechanism was put forward. This reaction constitutes a new transformation from 1,2-diarylalkynes into bisaryl ketones with a practical, neutral, and mild synthetic approach.
- Li, Xiangguang,Huang, Wenzhong,Liang, Deqiang,Yuan, Lin,Ma, Yinhai,Gu, Lijun
-
p. 1045 - 1049
(2015/01/30)
-
- Copper-catalyzed aerobic oxidative cleavage of C-C bonds in epoxides leading to aryl ketones
-
A novel copper-catalyzed aerobic synthesis of ketones from epoxides via cleavage of C-C single bonds has been discovered. This reaction constitutes a new transformation from epoxides into ketones.
- Gu, Lijun,Jin, Cheng,Zhang, Hongtao,Zhang, Lizhu
-
p. 8453 - 8456
(2015/03/18)
-
- Copper/palladium-cocatalyzed aerobic synthesis of bisaryl ketones from Olefins via C-C double bonds cleavage
-
A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described. This reaction constitutes a new transformation from 1,2-diarylalkenes into bisaryl ketones, providing a unifying, simple and environmentally friendly complement to the available methods.
- Gu, Lijun,Liu, Jiyan,Zhang, Hongtao
-
supporting information
p. 1267 - 1270
(2015/02/05)
-
- Silver-catalyzed decarboxylative acylation of arylglyoxylic acids with arylboronic acids
-
The silver-catalyzed coupling of arylboronic acids with arylglyoxylic acids was found to be an extremely efficient route for the synthesis of unsymmetrical diaryl ketones. It can be conducted on a gram scale under mild and open-flask conditions with good functional group compatibility, avoiding the addition of expensive and/or toxic metals. This journal is
- Cheng, Kai,Zhao, Baoli,Qi, Chenze
-
p. 48698 - 48702
(2014/12/10)
-
- Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization
-
Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.
- Li, Hu,Zhu, Ru-Yi,Shi, Wen-Juan,He, Ke-Han,Shi, Zhang-Jie
-
p. 4850 - 4853,4
(2012/12/12)
-
- Successful application of indirect electrooxidation for the transformation of biaryl methanols to the corresponding biaryl ketones
-
Various biaryl methanols were electrooxidized into the corresponding biaryl ketones in good yields and under very mild reaction conditions. Because of the relatively high oxidation potential, bulky structure, and somewhat poor solubility, biaryl methanols do not readily undergo direct electrooxidative transformations as a synthetic step toward the corresponding biaryl ketones. Herein, we report the successful indirect electrooxidation of secondary biaryl methanols featuring the use of a slight excess amount of KI (1.2 equivalents, relative to the substrate) in MeOH. Copyright
- Okimoto, Mitsuhiro,Yoshida, Takashi,Hoshi, Masayuki,Chiba, Tomohito,Maeo, Kei
-
experimental part
p. 3134 - 3139
(2011/10/01)
-
- Convenient method for the Friedel-Crafts acylation of benzene derivatives using silver nitrate as catalyst
-
(Chemical Equation Presented) Friedel-Crafts acylation of benzene derivatives such as anisole, toluene, and xylene has been successively carried out using silver nitrate as the catalyst in the presence of an eco friendly solvent (ethyl alcohol). Both benzoyl chloride and acetyl chloride reacted smoothly under the conditions to afford the corresponding ketones in good yield. Copyright Taylor & Francis Group, LLC.
- Rai, K.M. Lokanatha,Musad, Ebraheem Abdu,Jagadish,Shivakumar
-
experimental part
p. 953 - 955
(2011/04/23)
-
- Polystyrene supported Al(OTf)3: An environmentally friendly heterogeneous catalyst for Friedel-Crafts acylation of aromatic compounds
-
Stable and non-hygroscopic polystyrene supported aluminium triflate (Ps-Al(OTf)3), which is prepared easily from cheap and commercially available compounds was found to be an environmentally friendly heterogeneous catalyst for Friedel-Crafts acylation of arenes using acid chlorides in the absence of solvent under mild reaction conditions. The catalyst can be reused up to five times after simple washing with dichloromethane.
- Boroujeni, Kaveh Parvanak
-
experimental part
p. 3156 - 3158
(2012/05/20)
-
- A new tool for photoaffinity labeling studies: A partially constrained, benzophenone based, α-amino acid
-
The novel α-amino acid BpAib, a partially conformationally restricted analogue of the currently extensively used 3-(4-benzoylphenyl)alanine (Bpa) photoaffinity label, was synthesized, optically resolved, fully characterized, and appropriately derivatized.
- Wright, Karen,Moretto, Alessandro,Crisma, Marco,Wakselman, Michel,Mazaleyrat, Jean-Paul,Formaggio, Fernando,Toniolo, Claudio
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scheme or table
p. 3281 - 3286
(2010/08/22)
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- Silica gel supported AlCl3 catalyzed Friedel-Crafts acylation of aromatic compounds
-
Silica gel supported aluminium trichloride (SiO2-AlCl3) has been shown to be a mild, efficient, and chemoselective heterogeneous Lewis acid catalyst for the acylation of aromatic compounds with acid chlorides. The catalyst can be reused up to five times after simple washing with ether and is stable (as a bench top catalyst).
- Boroujeni, Kaveh Parvanak
-
experimental part
p. 1395 - 1398
(2011/10/09)
-
- Esters as acylating reagent in a Friedel-Crafts reaction: Indium tribromide catalyzed acylation of arenes using dimethylchlorosilane
-
(Chemical Equation Presented) The Friedel-Crafts acylation of arenes with esters by dimethylchlorosilane and 10 mol % of indium tribromide has been achieved. The key intermediate RCOOSi(Cl)Me2 is generated from alkoxy esters with the evolution of the corresponding alkanes. The scope of the alkoxy ester moiety was wide: tert-butyl, benzyl, allyl, and isopropyl esters were successful. In addition, we demonstrated the direct synthesis of the indanone intermediate 11 of salviasperanol from ester 10.
- Nishimoto, Yoshihiro,Babu, Srinivasarao Arulananda,Yasuda, Makoto,Baba, Akio
-
supporting information; experimental part
p. 9465 - 9468
(2009/04/06)
-
- Cu-Mg (24: 76) alloy: An efficient catalyst for Friedel-Crafts acylation of arenes
-
Friedel-Crafts acylation of different arenes was carried out in the presence of Cu-Mg (24:76) alloy under microwave irradiation and solvent-free conditions. Different substrates undergo acylation predominantly at the para-position. An efficient, simple, selective Friedel-Crafts acylation reaction affords good yields of the products and the catalyst could be easily recovered and recycled.
- Manjula, Krishnappa,Jayashankara, Vaderapura P.,Pasha, Mohamed A.
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p. 333 - 334
(2008/02/01)
-
- Hf[N(SO2C8F17)2] 4-catalyzed Friedel-Crafts acylation in a fluorous biphase system
-
In a fluorous biphase system, Hf[N(SO2C8F 17)2]4 complex (1 mol %) catalyzes Friedel-Crafts acylation of aromatic compounds such as anisole, toluene and chlorobenzene, and the corresponding aromatic ketones are obtained in satisfactory to high yields. The catalyst is selectively soluble in lower fluorous phase and can be easily recovered by simple phase separation. Furthermore, the catalyst can be reused without decrease of activity in most cases.
- Hao, Xiuhua,Yoshida, Akihiro,Nishikido, Joji
-
p. 2697 - 2700
(2007/10/03)
-
- The Friedel-Crafts acylation of aromatic compounds with carboxylic acids by the combined use of perfluoroalkanoic anhydride and bismuth or scandium triflate
-
Aromatic ketones were synthesized by solventless Friedel-Crafts acylation of anisole, mesitylene, xylenes, and toluene with acetic acid and benzoic acid in the presence of trifluoroacetic anhydride by use of bismuth or scandium triflate at 30°C. Toluene, benzene, and even deactivated substrate such as chlorobenzene were benzoylated by the combined use of heptafluorobutyric anhydride and bismuth triflate at 75-100°C. The catalyst could be easily recovered and reused repeatedly for the reaction.
- Matsushita, Yoh-Ichi,Sugamoto, Kazuhiro,Matsui, Takanao
-
p. 4723 - 4727
(2007/10/03)
-
- Friedel-crafts benzoylation of alkylbenzenes with brazoic anhydride catalyzed by solid superacids
-
The liquid-solid phase benzoylation of mono-alkylbenzenes with methyl, ethyl, propyl, and butyl groups and xylenes was carried out with benzoic anhydride at 100-110°C over solid superacids: SO4/ZrO 2, WO3/ZrO2, and SO4/ HfO 2. The reactivity ratio obtained by the competitive method of reaction over WO3/ZrO2 was 1 to 4.6 for toluene to p-xylene and 1.1:10:1 among o-, m-, and p-xylenes, respectively. Although the SO4/ZrO2 catalyst gave high yields of 92 and 97% for toluene and ethylbenzene in a 3:7 distribution of o- and p-isomers, respectively, low yields were observed with propyl and butylbenzenes over the catalyst: that is, 5 and 2% for propylbenzene and isopropylbenzene, 14% for isobutylbenzene, and trace yields for butylbenzene, s-butylbenzene, and t-butylbenzene, respectively. The usual Friedel-Crafts benzoylation using AlCl3 was examined in the present alkylbenzenes in order to confirm the low reactivity of both propyl and butylbenzenes. The results were similar to those with the SO4/ZrO2 catalyst; that is, the yields at 0°C for 1 h were 37, 21, 6, 1, 0, 3, and 2% for toluene, ethylbenzene, propylbenzene, isopropylbenzene, butylbenzene, s-butylbenzene, and t-butylbenzene, respectively, showing an unexpected result where there was no distinction between homogeneous and heterogeneous conditions.
- Nakamura, Hideo,Arata, Kazushi
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p. 1893 - 1896
(2007/10/03)
-
- Synthesis of Diaryl Ketones Catalyzed by Al2O 3-ZrO2/S2O82- Solid Superacid
-
The acylation of a variety of aromatic compounds with benzoyl chloride or its derivatives and catalytic amounts of Al2O3-ZrO 2/S2O82- solid superacid affords the corresponding diaryl ketones in good to excellent yields 75-93% at appropriate temperature.
- Jin, Tong-Shou,Yang, Mi-Na,Feng, Guo-Liang,Li, Tong-Shuang
-
p. 479 - 485
(2007/10/03)
-
- Antimony(V) chloride-benzyltriethylammonium chloride complex as an efficient catalyst for friedel-crafts acylation reactions
-
A novel catalytic system, the complex of antimony(V) chloride (SbCl 5) and benzyltriethylammonium chloride (TEBA), C6H 5CH2NEt3(SbCl5)2Cl complex, is described for Friedel-Crafts acylation reactions of aromatics with acyl and sulfonyl chlorides. The catalyst has a number of useful characteristics, such as ready access, minimal toxicity, reusability, insensitivity to atmosphere and moisture, rapid acylation with high yield, and ease of operation.
- Huang, An-Ping,Liu, Xue-Yuan,Li, Lian-Hua,Wu, Xiao-Li,Liu, Wei-Min,Liang, Yong-Min
-
p. 599 - 602
(2007/10/03)
-
- BiCl3-catalyzed Friedel-Crafts acylation reactions: Bismuth(III) oxychloride as a water insensitive and recyclable procatalyst
-
The Friedel-Crafts acylation of activated and polycyclic aromatics is efficiently catalyzed by bismuth(III) chloride which is generated in situ from bismuth(III) oxychloride, a water insensitive and eco-friendly material. Bismuth(III) oxychloride is easily recovered in near quantitative yields after an aqueous work-up.
- Répichet, Sigrid,Le Roux, Christophe,Roques, Nicolas,Dubac, Jacques
-
p. 2037 - 2040
(2007/10/03)
-
- Zinc Mediated Friedel-Crafts Acylation in Solvent-Free Conditions under Microwave Irradiation
-
Zn powder is found to catalyze the Friedel-Crafts acylation of aromatic compounds with acyl halides efficiently under microwave irradiation in solvent-free conditions. Activated substrates undergo acylation predominantly at the para-position. The Zn powder can be re-used up to six times after simple washing with diethyl ether and dilute HCl.
- Paul, Satya,Nanda, Puja,Gupta, Rajive,Loupy, Andre
-
p. 2877 - 2881
(2007/10/03)
-
- Trifluoromethanesulfonic acid catalyzed novel friedel-crafts acylation of aromatics with methyl benzoate
-
Methyl benzoate, protolytically activated by superacidic trifluoromethanesulfonic acid, reacts with aromatic compounds to give benzophenone derivatives in good to excellent yields (70-93%). Even highly deactivated nitrobenzene as well as benzotrifluoride
- Hwang, Je Pil,Surya Prakash,Olah, George A.
-
p. 7199 - 7203
(2007/10/03)
-
- Toward a clean alternative to Friedel-Crafts acylation: In situ formation, observation, and reaction of an acyl bis(trifluoroacetyl)phosphate and related structures
-
Reaction of acyl trifluoroacetates with phosphoric acid in the presence of trifluoroacetic anhydride (TFAA) leads to the ready formation of acyl bis(trifluoroacetyl)phosphates, which are powerful acylating agents. Formation of these species and the subsequent acylation reaction are carried out, without added solvent, in a single in situ reaction process. In this reaction system, anisole is rapidly acylated at ambient temperature using a variety of carboxylic acids giving the para isomer exclusively. TFAA acts as an activating agent and can be recovered from the reaction system as trifluoroacetic acid (TFA) and converted back to TFAA using a dehydrating agent, while phosphoric acid behaves as a covalent catalyst in the process. This reaction system has many features which are required elements of a clean alternative to the Friedel-Crafts process.
- Smyth, Timothy P.,Corby, Brian W.
-
p. 8946 - 8951
(2007/10/03)
-
- Graphite as an effective catalyst for Friedel-Crafts acylation
-
Graphite is found to promote Friedel-Crafts acylation of aromatic compounds such as anisole, toluene and o-xylene with acyl halides to give the corresponding acylated products in high yields.
- Kodomari, Mitsuo,Suzuki, Yoshitada,Yoshida, Kouji
-
p. 1567 - 1568
(2007/10/03)
-
- (Trichloromethyl)benzene: A versatile reagent for the preparation of substituted benzophenones
-
Aromatic and heteroaromatic compounds were benzoylated efficiently with (trichloromethyl)benzene in 1,2-dichloroethane in the presence of aluminium chloride in good yield.
- Ayyanger,Lahoti,Srinivasan,Daniel
-
p. 322 - 324
(2007/10/02)
-
- Haloalkyl benzophenone compounds suitable for use as initiators for photopolymerization
-
This invention relates to 3,4-bis(halomethyl) benzophenone photoinitiators and these initiators admixed with unsaturated photopolymerizable compounds. When such compositions are irradiated by ultraviolet light, the benzophenone derivatives split off free radicals which initiate the photopolymerization of the unsaturated photopolymerizable compounds.
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