Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.
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Page/Page column 82
(2016/01/25)
Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators
Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmaco
Bridoux, Alexandre,Cui, Huadong,Dyskin, Evgeny,Schmitzer, Andreea-Ruxandra,Yalcin, Murat,Mousa, Shaker A.
supporting information; experimental part
p. 3394 - 3398
(2010/08/22)
Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates
Several novel gadolinium chelates conjugated with paclitaxel, colchicine and thyroxine have been prepared as MRI contrast agents targeted to tubulin and thyroxine-binding globulin, respectively.