- Synthesis process of 2, 3-difluoro-4-alkoxy phenol
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The invention discloses a synthesis process of 2, 3-difluoro-4-alkoxy phenol, and belongs to the technical field of organic synthesis. The process comprises the following steps: using 2, 3-difluorophenylalkyl ether as a raw material, carrying out lithiation by use of n-butyllithium under an ultralow temperature condition, reacting with boric acid ester, adding an alkali for quenching to obtain 2,3-difluoro-4-alkoxy benzene borate, oxidizing in the presence of hydrogen peroxide, and performing acidolysis to obtain 2, 3-difluoro-4-alkoxy phenol, so that the purity of the purified product can reach more than 99.95 %, the impurity content is less than 50ppm, and the requirements of electronic-grade products are met. Boric acid and the alkali can form salt, the salt is dissolved in water and subjected to a homogeneous reaction for an oxidation reaction during oxidation in the presence of the hydrogen peroxide, the reaction conditions are mild, impurities are few, the product purity is high, the solvent can be recycled, and industrial production is easy to achieve.
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Paragraph 0026; 0029
(2020/04/06)
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- Process for the preparation of 2,3-difluorobenzenes
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1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.
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