- Method for synthesizing 1,4-di(difluoro phenoxy methyl) benzene
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The invention provides a method for synthesizing 1,4-di(difluoro phenoxy methyl) benzene. The method comprises the following steps: (1) by taking 1,4-di(difluoro methyl) benzene as an initial raw material, and carrying out a free radical substation reaction with chlorine in the presence of a free radical initiator so as to obtain 1,4-di(chlorine difluoro methyl) benzene; (2) without refining of the intermittent, namely the 1,4-di(chlorine difluoro methyl) benzene, directly carrying out a unimolecule free radical nucleophilic substitution reaction on the intermittent with an alkali and phenol in an organic solvent, and carrying out recrystallization on a crude product, thereby obtaining the 1,4-di(difluoro phenoxy methyl) benzene. The method is gentle in reaction condition, and the obtainedproduct is high in both yield and purity and is applicable to large-scale production.
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Paragraph 0029; 0032; 0035; 0038; 0041; 0044; 0047; 0051
(2018/11/03)
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- FACILE AND EFFECTIVE METHOD OF PREPARING 1,4-BIS(CHLORODIFLUOROMETHYL)BENZENE
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The present invention relates to a facile method of preparing 1,4-bis(chlorodifluoromethyl)benzene, comprising the steps of: (A) providing a reactant liquid of 1,4-bis(difluoromethyl)benzene; optionally (B) providing a light source for UV radiation; and (C) introducing chlorine gas into the reactant liquid at a temperature of 50-90° C. under a pressure above 1 atm to obtain 1,4-Bis(chlorodifluoromethyl)benzene. The invented facile method can be utilized in a batch process or a continuous process for effective production of 1,4-bis(chlorodifluoromethyl)benzene.
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Paragraph 0036; 0037; 0038
(2013/05/21)
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- Efficient synthesis of p-bis-(chlorodifluoromethyl)benzene
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Selective, high yield partial fluorination of p-bis-(trichloromethyl)benzene to p-bis-(chlorodifluoromethyl)benzene has been accomplished by warming a slurry of the p-bis-(trichloromethyl)benzene in anhydrous HF which also contains a small quantity of inert solvent, such as 1,2-dichloroethane.
- Dolbier Jr., William R.,Duan, Jian-Xin,Rong, Xiao X.
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p. 1091 - 1093
(2008/02/08)
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- Processes for the preparation of octafluoro-[2,2]paracyclophane
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Processes are disclosed for the preparation of octafluoro-[2,2]paracyclophane which utilize a low temperature, e.g., less than about 200° C., and a reducing agent comprising titanium to promote the dimerization of dihalo-tetrafluoro-p-xylenes. One suitable reducing agent is prepared by combining TiCl4 with LiAlH4 in an organic solvent.
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