Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives
Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone ((5)-2) and (R)4- acetylthio-2-pyrrolidinone (S), which are key intermediates of oral carbapenem CS-834, were studied. The most efficient route to (S)-2 from (S)- 3-hydroxybutyrolactone (8) was accomplished in high yield via (S)-N-allyl-3- (1-ethoxy)ethoxy-4-hydroxybutyramide (14).
Kanno, Osamu,Miyauchi, Masao,Kawamoto, Isao
p. 173 - 181
(2007/10/03)
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