A convenient route for the synthesis of some new Bi-and triheterocondensed uracils
Some bifunctional heterocyclic systems having vicinal chlorocyano, chloroacetyl, and chloro-ethoxycarbonyl groups in their structures reacted with 6-amino-1,3-dimethyluracil to afford novel triheterocyclic systems having a pyrimidinedione moiety. Enaminones and a-cyanocinnamic acid derivatives in this reaction gave pyrido[2,3-d]pyrimidinediones. The antimicrobial activity of some new synthesized triheterocyclic systems was studied. 2010 Springer Science+Business Media, Inc.
Abdel-Megid
experimental part
p. 316 - 324
(2011/05/14)
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