Electrochemical synthesis of glycoconjugates of 3β-hydroxy- Δ5-steroids by using non-activated sugars and steroidal thioethers
A new protocol for the electrochemical synthesis of glycoconjugates is presented. Thioether derivatives of cholesterol and other sterols were subjected to anodic oxidation in the presence of a sugar alcohol affording glycoconjugates with the sugar linked to a steroid moiety by an ether bond. The isomeric 6β-3α,5α-cyclo-steroidal thioethers proved to be better sterol donors than the normal 3β-Δ5-steroidal thioethers.
Tomkiel, Aneta M.,Brzezinski, Krzysztof,?otowski, Zenon,Siergiejczyk, Leszek,Wa?ejko, Piotr,Witkowski, Stanis?aw,Kowalski, Jan,P?oszyn?ska, Jolanta,Sobkowiak, Andrzej,Morzycki, Jacek W.
p. 8904 - 8913
(2013/09/23)
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