Synthesis of water soluble derivatives of milbemycin D
Water Soluble 5-O-(S-glutathionylthio)cysteinyl-milbemycin D was successfully synthesized by using 3-nitro-2-pyridinesulfenyl (Npys) reagent through esterification of a Boc-cysteine derivative to a hydroxyl group at the C-5 position of milbemycin D, activation of the conventional S-protecting group, and asymmetrical disulfide bond formation.
Matsueda, Rei,Higashida, Susumu
p. 511 - 514
(2007/10/03)
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