- 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS
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The compound 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and pharmaceutically usable salts and/or tautomers thereof. The use of this compound for the treatment of tumours, tumour growth, tumour metastases and/or AIDS.
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Paragraph 0166
(2015/09/28)
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- The amination of halogeno-2,7- and 1,8-naphthyridines
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The conversion of 1-halogeno-2,7-naphthyridines into the corresponding 1-amino compounds with KNH2/NH3, is shown, by the use of deuterated starting compounds, to proceed via an SN(AE)ipso substitution and not via an SN(AE)tele mechanism, even though convincing evidence for the formation of tele ?-adduct, 8-amino-1-halogeno-dihydro-2,7-naphthyridine, was obtained.Using the same methods, it is shown that the conversion of 2-bromo-1,8-naphthyridine into 2-amino-1,8-naphthyridine proceds, to the extent of 40percent via an odd SN(AE)tele pathway.
- Haak, H. J. W. van den,Plas, H. C. van der
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p. 235 - 238
(2007/10/02)
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- Amination of 2,6- and 2,7-Naphtyridine. An NMR Study on ?-Adducts of Heterocyclic Systems with Amide Ions
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A facile synthesis of 2,6-naphtyridine is described.Both 2,6- and 2,7-naphtyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions ?-adduct formation at position 1.Chichibabin amination of 2,6-naphtyridine yields 1-amino-2,6-naphtyridine in 54percent yield.
- Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
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p. 1349 - 1352
(2007/10/02)
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