Nucleophilic trifluoromethylation of azinium salts with Zn(CF3)2·bpy
(Trifluoromethyl)zinc complexes have been widely used in metal-mediated trifluoromethylation reactions. However, direct nucleophilic addition with a (trifluoromethyl)zinc complex is rare. In this article, we describe an unprecedented trifluoromethylation of azinium salts using Zn(CF3)2·bpy as CF3 source, giving 1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinolines as products. The latter species were further transformed to 2-trifluoromethylquinolines under oxidative conditions. This work also shows that ligands play an important role in tuning the reactivity of (trifluoromethyl)zinc complexes.
Pan, Shitao,Wang, Xiu,Ni, Chuanfa,Hu, Jinbo
supporting information
(2021/10/12)
Construction of Tropane Derivatives by the Organocatalytic Asymmetric Dearomatization of Isoquinolines
A chiral-NHC-catalyzed highly diastereo- and enantioselective dearomatizing double Mannich reaction of isoquinolines was developed that provides a powerful and straightforward synthetic route toward substituted tropane derivatives with four contiguous ste
Xu, Jin-Hui,Zheng, Sheng-Cai,Zhang, Ji-Wei,Liu, Xin-Yuan,Tan, Bin
supporting information
p. 11834 - 11839
(2016/11/16)
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