The present invention provides compounds, compositions thereof, and methods of using the same for the modulation of STING, and the treatment of STING-mediated disorders.
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(2020/07/14)
Synthesis and antibacterial activity of novel 1 β-methyl carbapenems with cycloalkylamine moiety at the C-2 position
Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.