- Enantioselective syntheses of β-amino alcohols catalyzed by recyclable chiral Fe(III) metal complex
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An efficient asymmetric desymmetrization of meso-epoxides with anilines catalysed by a series of simple and environmentally benign in situ generated Fe(iii) complexes based on chiral tridentate ligands L1-L7 with achiral and chiral l
- Tak, Rajkumar,Kumar, Manish,Kureshy, Rukhsana I.,Choudhary, Manoj Kumar,Khan, Noor-Ul H.,Abdi, Sayed H. R.,Bajaj, Hari C.
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p. 7693 - 7700
(2016/07/13)
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- Screening of a library of hemisalen ligands in asymmetric H-transfer: Reduction of aromatic ketones in water
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A library of chiral hemisalen ligands (30) was realized. The ligands were synthesized by the condensation of salicylaldehyde derivatives with amino-alcohols (amino-indanol or substituted amino-ethanol) and characterized. These ligands associated with ruthenium (II) precursors were tested on the asymmetric transfer hydrogenation (ATH) of aromatic ketones by sodium formate in water. The different substituent pattern on the ligand (electronic and hindrance effects on different positions) as well as the ruthenium precursor were investigated. The best compromise in terms of conversion and chiral induction led to the complex [RuCl2(mesitylene)]2 coordinated to (1S,2R)-1-((E)-(3-(dimethyl(phenyl)silyl)-2-hydroxy-5-methoxy benzylidene) amino)-2,3-dihydro-1H-inden-2-ol (L25). It reduces acetophenone in 95% yield and 91% ee in 18 h at 30°C.
- Boukachabia, Mourad,Vriamont, Nicolas,Lambin, Dominique,Riant, Olivier,Aribi-Zouioueche, Louisa
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p. 403 - 412
(2014/05/06)
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- Synthesis of chiral ligands with multiple stereogenic centers and their application in titanium(iv)-catalyzed enantioselective desymmetrization of meso-epoxides
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New chiral ligands, (S,R,S)-1, (S,S,S)-1, (S,S,R)-1, (S,R,R)-1, (R,R,R)-1, (R,R,S)-1, (R,S,S)-1, (R,S,R)-1, (S,R,S)-2, (S,S)-3 and (R,S)-4 with diverse stereogenic centers arising from various diastereomeric combinations of aminoalcohol functionality with
- Kumar, Manish,Kureshy, Rukhsana I.,Ghosh, Debashis,Khan, Noor-UL H.,Abdi, Sayed H. R.,Bajaj, Hari C.
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p. 2336 - 2342
(2013/08/23)
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