- Antifungal amino acid derivative
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PROBLEM TO BE SOLVED: To provide a new antifungal compound and an amino acid derivative with antifungal properties.SOLUTION: This invention relates to a compound represented by NHR-CHR-C(O)-R(I) or salt thereof, and an antifungal agent including the compound or salt thereof.
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Paragraph 0138-0141
(2018/06/12)
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- β-lactam derivatives as enzyme inhibitors: Carboxy peptidyl derivatives of (S)-4-Oxoazetidine-2-carboxylate as peptidomimetics
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4-Oxoazetidine-2-carboxylic acid, protected at the nitrogen by silyl groups, was coupled with amino acid and oligopeptide esters. Desilylation and deprotection of the amino acid residues yielded the free β-lactam peptides. Structure and properties were elucidated by spectroscopic methods and discussed. Some selected compounds Were tested as fibrinogen inhibitors and for thrombocyte aggregation. None of the compounds showed any activity up to a concentration of 10-5 Mol/1. Some other compounds exhibited a weak inhibitory activity against elastase (PPE).
- Schneider, Martin,Otto, Hans-Hartwig
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p. 167 - 172
(2007/10/03)
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- Novel Preparation of N-Protected Amino Acid Active Esters Using 1,2,2,2-Tetrachloroethyl Carbonates
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1,2,2,2-Tetrachloroethyl chloroformate reacts with substituted phenols or N-hydroxy imides to yield crystalline and stable mixed aryl or oximido tetrachloroethyl carbonates.When allowed to react with an N-protected amino acid derivative, these compounds proved to be efficient for the syntheses of the corresponding active esters.A series of active esters including p-nitrophenol, trichlorophenol, pentafluorophenol, and N-hydroxysuccinimide derivatives were prepared by this new procedure.
- Jaoudai, Mahmoud,Martinez, Jean,Castro, Bertrand
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p. 2364 - 2367
(2007/10/02)
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