ON THE REACTIVITY OF HALO-1,3-AZOLES AND RELATED COMPOUNDS TOWARD AROMATIC SN2 SUBSTITUTION
Nucleophilic addition-elimination reactions of 2-methylsulfonyl-1,3-azoles with active methylene compounds were investigated in order to compare the reactivity of substrates.The order of oxazole > thiazole >> N-methylimidazole in the reactivity was exhibited clearly.Furthermore, in oxazole and thiazole series, the predominant reactivity of the 2-position over the 4- and 5-positions was indicated on the reaction with the carbanions generated from active methylene compounds.
Yamanaka, Hiroshi,Ohba, Setsuya,Sakamoto, Takao
p. 1115 - 1127
(2007/10/02)
Synthesis and antiparasitic and molluscicidal activities of polycyclic derivatives of pyridine. 1. Comparison of 2-substituted thiazolo [5,4-b) pyridine and benzothiazole derivatives
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Gayral,Bourdais,Lorre,et al.
p. 171 - 175
(2007/10/04)
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