- A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS
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The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C1-C6 alkoxycarbonyl, and carbobenzyloxy; R6 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, and benzyl; and R9, R 10, and R11 are independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl. wherein the process involves cyclizing I-I, formula (II).
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Page/Page column 14-15
(2008/12/07)
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- Asymmetric Synthesis of 3-Carboxyproline and Derivatives Suitable for Peptide Synthesis
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An asymmetric synthesis of both diastereomers of 3-carboxyproline, as well as 5-substituted derivatives and partially protected derivatives suitable for peptide synthesis starting from aspartic acid is reported.
- Cotton, Ron,Johnstone, Andrew N. C.,North, Micheal
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p. 8525 - 8544
(2007/10/02)
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- Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: Modification of the P1 and P2' residues
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Systematic modification of the presumed P1 side chain in a series of (carboxyalkyl)amino-based inhibitors of matrix metalloproteinases enabled identification of the 2-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)ethyl group as a preferred substituent imparting potent inhibition of the enzymes collagenase and gelatinase. It was subsequently found that the P2'-P3' residues in this series could be replaced by small non-peptide residues, while maintaining inhibitory potency. The imide group in this series of compounds can undergo autocatalytic hydrolysis under neutral conditions.
- Brown,Brown,Bickett,Chambers,Davies,Deaton,Drewry,Foley,McElroy,Gregson,McGeehan,Myers,Norton,Salovich,Schoenen,Ward
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p. 674 - 688
(2007/10/02)
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- Racemic Origins of the Stereochemically Homogeneous Biosphere. Biased Stereoselectivities in the Formation of Oligomeric Peptides
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Each of the competitive processes used to form the 34-di-, tri-, and tetrapeptides of alanine, aspartic acid, and glycine, 3 of the most abundant amino acid products of geosimulation experiments, was found to be stereoselective.The majority of them (70per
- Goldberg, Stanley I.,Crosby, Jane M.,Iusem, Norberto D.,Younes, Usama E.
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p. 823 - 830
(2007/10/02)
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- ENANTIOSPECIFIC SYNTHESIS OF A CHIRAL CARBAPENEM PRECURSOR FROM (R)-ASPARTIC ACID
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A short enantiospecific preparation of a key intermediate to carbapenem antibiotics with (R)-aspartic acid as chiral educt is described.
- Pellicciari, Roberto,Natalini, Benedetto,Ursini, Antonella
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p. 607 - 608
(2007/10/02)
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