4 - AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2A RECEPTOR ANTAGONISTS
New 4-amino-pyrimidine derivatives as potent antagonists of the adenosine A2a receptor of formula (I). The invention provides as well a method for preparing such compounds, pharmaceutical compositions comprising an effective amount of these com
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Page/Page column 24-25
(2011/10/13)
MECHANISM FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 4. ACTIVATING INFLUENCES OF RING-NITROGEN AND TRIFLUOROMETHYL IN NUCLEOPHILIC AROMATIC SUBSTITUTION
Rate constants have been measured for the reactions of ammonia with various fluorinated pyridines and diazines in aqueous dioxan at 25 deg C.From the results the activating effects of ring-nitrogen (relative to C-H) and of trifluoromethyl (relative to -H)
Chambers, R. D.,Martin, P. A.,Waterhouse, J. S.,Williams, D. L. H.,Anderson, B.
p. 507 - 514
(2007/10/02)
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