Synthesis and biological activities of an α-methyl and a β-methyl carbapenem and the corresponding unsubstituted compound
The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality. (C) 2000 Elsevier Science Ltd. All rights reserved.
Pfaendler, Hans Rudolf,Weishaupt, Ralf,Meffert, Helmut
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