- DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
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The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering
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- Compounds and methods for modulation of estrogen receptors
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Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-β over ER-α. Methods are disclosed for modulating ER-β in cell and/o
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- Compounds and methods for modulation of estrogen receptors
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Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-β over ER-α. Methods are disclosed for modulating ER-β in
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- Process for producing hydroxyphenyl aliphatic acid derivatives
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A catalyst of bis(8-quinolinolate) copper (II) complex having the formula STR1 which is used for producing a hydroxyphenyl aliphatic acid derivative having the formula STR2 wherein R1 represents hydrogen atom, a lower alkyl group, a lower alkoxy group, hydroxy group or a lower alkylcarbonyl group; R2 and R3 are the same or different and respectively represent hydrogen atom or a lower alkyl group; and m is 1 or 2; l is 0, 1 or 2; n is 0, 1 or 2; by reacting a halophenyl aliphatic acid derivative having the formula STR3 wherein R1, R2, R3, m, l and n are defined above and R4 represents hydrogen atom or a monovalent hydrocarbon moiety; and X represents a halogen atom, with a base.
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