- AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5
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The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
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Page/Page column 24
(2009/05/29)
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- Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
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This invention involves compounds having the following structure: as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.
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- A facile route to cyclic and acyclic alkyl-arginines
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Treatment of commercially available alkyl and cycloalkyl thioureas with methyl iodide provides the corresponding S-alkylisothiouronium iodide which reacts directly with ornithine to yield the title compounds.
- Kennedy, Kevin J.,Simandan, Tiberiu L.,Dix, Thomas A.
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p. 741 - 746
(2007/10/03)
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