- Ti-amide catalyzed synthesis of cyclic guanidines from di-/triamines and carbodiimides
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A titanacarborane monoamide catalyzed, one-step synthesis of mono/bicyclic guanidines from commercially available di/triamines and carbodiimides is reported. The reaction mechanism is also proposed.
- Shen, Hao,Wang, Yang,Xie, Zuowei
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scheme or table
p. 4562 - 4565
(2011/10/12)
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- Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation
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Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.
- Thomas,Nishizawa,Zimmermann,Williams
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p. 228 - 236
(2007/10/02)
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