- ISOCYANATE PRODUCTION METHOD
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An isocyanate production method according to the present invention is a method in which an isocyanate is produced by subjecting a carbamate to thermal decomposition, and includes: a step of preparing a mixture liquid containing the carbamate, an inactive solvent and a polyisocyanate compound; a step of conducting a thermal decomposition reaction of the carbamate by continuously introducing the mixture liquid into a thermal decomposition reactor; a step of collecting a low-boiling decomposition product by continuously extracting the low-boiling decomposition product in a gaseous state from the reactor, the low-boiling decomposition product having a boiling point lower than the polyisocyanate compound; and a step of collecting a high-boiling component by continuously extracting, from the reactor, a liquid phase component which is not collected in a gaseous state at the step of collecting the low-boiling decomposition product.
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Paragraph 0434-0443; 0446; 0480-0481
(2020/05/02)
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- PRODUCTION METHOD OF ISOCYANATE
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PROBLEM TO BE SOLVED: To provide a production method of isocyanate for producing isocyanate continuously by suppressing a side reaction. SOLUTION: A production method of isocyanate is a method for producing isocyanate by pyrolysis of carbamate. The method includes a pyrolysis process for performing a pyrolysis reaction of carbamate by introducing continuously a mixed liquid containing carbamate and a compound (A) having a specific structure into a pyrolysis reactor, a low-boiling point decomposition product recovery process for extracting, continuously from the pyrolysis reactor in a gas phase, a low-boiling point decomposition product having a lower normal boiling point than the compound (A), and a high-boiling point component recovery process for extracting, continuously from the pyrolysis reactor as a high-boiling point component, a liquid phase component not recovered in the gas phase in the low-boiling point decomposition product recovery process. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0166; 0171; 0172
(2020/02/14)
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- METHOD FOR PRODUCING ISOCYANATE
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PROBLEM TO BE SOLVED: To provide a method for producing isocyanate that suppresses a side reaction and continuously produces isocyanate. SOLUTION: The present invention provides a method for producing isocyanate by pyrolysis of carbamate, the method including: a pyrolysis step in which a liquid mixture containing carbamate and at least one compound (A) selected from a phenolic polymer having a repeating unit represented by general formula (4) and a phenol represented by general formula (5) is continuously introduced into a pyrolytic reactor for a pyrolytic reaction of carbamate; a low-boiling-point pyrolytic product recovery step in which a low-boiling-point pyrolytic product having a normal boiling point lower than that of the compound (A) is continuously extracted in a gas state from the pyrolytic reactor; and a high-boiling-point component recovery step in which a liquid phase component, which has not been recovered in a gas state in the low-boiling-point pyrolytic product recovery step, is continuously extracted as a high-boiling-point component from the pyrolytic reactor. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0173-0175; 0178-0179
(2020/03/13)
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- Synthesis of a new urea derivative: A dual-functional organocatalyst for Knoevenagel condensation in water
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A phenylalanine-urea compound-catalyzed Knoevenagel condensation in water is reported. Various aldehydes and active methylene compounds undergo condensation at room temperature to give the desired products in high yields. The mechanism of the condensation of aldehydes with Meldrum's acid catalyzed by the novel urea derivative is also disclosed.
- Le, Wen-Jun,Lu, Hong-Fei,Zhou, Jun-Tao,Cheng, He-Long,Gao, Yu-Hua
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supporting information
p. 5370 - 5373
(2013/09/12)
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- 3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO-[5,1-D][1,2,3,5-TETRAZINE-8-CARBOXYLIC ACID AMIDES AND THEIR USE
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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.
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Page/Page column 100
(2009/07/18)
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- Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters
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A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.
- Lebedev,Lebedeva,Sheludyakov,Ovcharuk,Kovaleva,Ustinova
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p. 1069 - 1080
(2008/02/05)
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- Carbamate ester prodrugs of dopaminergic compounds: Synthesis, stability, and bioconversion
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Various carbamic acid esters (CAE) of a new class of dopaminergic drugs, 5-substituted 8-chloro-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines, were synthesized and evaluated as prodrug forms with the aim of protecting the parent phenols against first-pass metabolism following oral administration. Monosubstituted CAE were found to be highly unstable at pH 7.4 and 37 °C, the half-lives of hydrolysis being between 4 and 40 min. Plasma from various species catalyzed the hydrolysis of the carbamates. N,N-Disubstituted carbamates, on the other hand, were stable both in buffer and plasma solutions. They showed a very potent inhibition of butyrylcholinesterase (EC 3.1.1.8), but were less potent inhibitors of the specific erythrocyte acetylcholinesterase (EC 3.1.1.17). In vitro incubations of an N,N-dimethylsubstituted carbamate ester (10) with liver microsomes from mouse and rat showed an appreciable formation of the parent phenolic compound. This bioconversion is suggested to occur via an initial cytochrome P-450-catalyzed hydroxylation to give an N-hydroxymethyl derivative which spontaneously decomposes to the N-monomethylcarbamate. It is concluded that N,N-disubstituted carbamate esters may be potentially useful prodrugs for the 7-hydroxy-3-benzazepines, whereas N-monosubstituted carbamates appear to be too chemically and enzymatically labile.
- Hansen,Faarup,Bundgaard
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p. 793 - 798
(2007/10/02)
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