Hydrolysis of 2'-Deoxypurine Nucleosides. The Effect of Substitution at the C-8 Position.
The hydrolytic stability of 2'-deoxypurine nucleosides is decreased by introduction of electronwithdrawing substituents at the C-8 position in the series of compounds 2-8, 10-14.The sulfone group causes a 2.9 x 104 rate acceleration for glycosidic, bond cleavage in compound 14.
Laayoun, Ali,Decout, Jean-Luc,Lhomme, Jean
p. 4989 - 4990
(2007/10/02)
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