- Identification and synthesis of new sex-specific components of olive fruit fly (Bactrocera oleae) female rectal gland, through original Negishi reactions on supported catalysts
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In the present study, eleven new sex-specific components extracted from female rectal gland of olive fruit flies were synthesized and identified. The quantitative determination of those components by GC and GC/EI-MS, at different moments of the insect life span, highlighted the growing trend of their secretion. While for the synthesis of saturated esters, conventional transesterification methods could be adopted, for the synthesis of unsaturated components, a Negishi cross-coupling between organozinc halides and (Z)-1-bromo-1-alkenes was developed. To the extent of our knowledge, this reaction represents the first example of supported-catalyst promoted Negishi coupling, between an alkylzinc reagent and an alkenyl halide.
- Fusini, Graziano,Barsanti, Davide,Angelici, Gaetano,Casotti, Gianluca,Canale, Angelo,Benelli, Giovanni,Lucchi, Andrea,Carpita, Adriano
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supporting information
p. 4381 - 4389
(2018/07/21)
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- Synthesis, antimicrobial evaluation, QSAR and in silico ADMET studies of decanoic acid derivatives
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Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topological steric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.
- Kumar, Ashwani,Singh, Surender,Jain, Sandeep,Kumar, Parvin
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experimental part
p. 191 - 204
(2011/10/09)
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- A Simple and Efficient Esterification Method
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A convenient and practical esterification was realized and this reaction proceeded without a dehydrating reagent or water removal equipment. The synthesis of esters by reaction of carboxylic acids with various alcohols such as methyl, ethyl, isopropyl, isobutyl, allyl, benzyl, propargyl and decanyl alcohols were achieved with a catalytic amount of CBr4 under refluxing reaction condition.
- Ming-Yi, Chen,Lee, Adam Shih-Yuan
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p. 103 - 108
(2007/10/03)
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