- Multicolor luminescent supramolecular hydrogels based on cucurbit[8]uril and OPV derivative
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Supramolecular hydrogels have received considerable attention because of their various fascinating applications. Herein, an alkyl chain-modified oligo(p-phenylenevinylene) (Py-OPV) derivative was synthesized. When assembled with cucurbit[7]uril, its fluor
- Chang, Yong-Zhen,Chen, Yong,Liu, Yu
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- A highly selective and sensitive fluorescent chemosensor for Hg2+ based on a pyridine-appended π-conjugated ligand
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A pyridine-appended π-conjugated ligand 1,4-bis[2-(4-pyridyl)ethenyl]benzene (bpeb) has proved to be highly selective and sensitive as a chemosensor for Hg2+ in buffered aqueous solution. Remarkable changes in the UV-vis and fluorescence emission spectra were observed upon addition of Hg2+ ions to a solution of bpeb. In particular, the interaction of the lone-pair electrons on the pyridine nitrogen with Hg2+ ions results in a significant red-shift in the fluorescence spectrum and a large Stokes shift of up to 65 nm. DFT calculations have revealed that the energy levels of the HOMO and LUMO of bpeb are critically decreased upon coordination to Hg2+ ions, thereby accounting for this red-shift of the fluorescence spectrum. Furthermore, bpeb has been shown to be applicable as a fluorescent probe for imaging Hg2+ ions in PC3 cell lines, which may help in the understanding of relevant biological processes at the molecular level. This journal is
- Yang, Yaping,Ni, Xin-Long,Sun, Tao,Cong, Hang,Wei, Gang
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- New viologen analogs: 1,4-bis[2-(pyridin-4-yl)ethenyl]benzene quaternary salts
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Alkylation of 1,4-bis[2-(pyridin-4-yl)ethenyl]benzene with alkyl p-toluenesulfonates and dimethyl sulfate gave new viologen analogs, 1-alkyl-4-(2-{4-[2-(1-alkylpyridinium-4-yl)ethenyl]phenyl}ethenyl)-pyridinium bis(p-toluenesulfonates) and sulfate. Their
- Gutov,Rusanov,Chepeleva,Garasevich,Ryabitskii,Chernega
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- Synthesis of some new distyrylbenzene derivatives using immobilized Pd on an NHC-functionalized MIL-101(Cr) catalyst: photophysical property evaluation, DFT and TD-DFT calculations
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In this study the catalytic application of a heterogeneous Pd-catalyst system based on metal organic framework [Pd-NHC-MIL-101(Cr)] was investigated in the synthesis of distyrylbenzene derivatives using the Heck reaction. The Pd-NHC-MIL-101(Cr) catalyst s
- Niknam, Esmaeil,Mahmoodi, Ali,Panahi, Farhad,Heydari Dokoohaki, Maryam,Zolghadr, Amin Reza,Khalafi-Nezhad, Ali
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p. 12374 - 12380
(2021/04/07)
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- Immobilized Pd on a NHC-functionalized metal-organic FrameworkMIL-101(Cr): An efficient heterogeneous catalyst in the heck and copper-free Sonogashira coupling reactions
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A heterogeneous palladium catalyst system based on immobilization of palladium moieties on a N-heterocyclic carbene (NHC) modified metal organic framework (MOF) was developed for the Heck and copper-free Sonogashira coupling reactions. In order to prepare this catalyst system, first, MIL-101(Cr) was functionalized with NHC moieties through a post synthetic modification (PSM) approach, and then Pd metal was stabilized on the prepered MIL-101(Cr)-NHC substrate. This material was characterized using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphology and structure of MIL-101(Cr) template during the reaction progress. Also, existence of palladium nanoparticles immobilized on the MOF structure affirmed by the TEM and XPS analysis confirmed the oxidation state of Pd. A variety of alkene and alkyne derivatives were synthesized in good to excellent yields using this heterogeneous Pd catalyst system under normal conditions. More importantly Pd-NHC-MIL-101(Cr) catalyst was simply recovered from the reaction medium without remarkable decreasing in its catalytic activities after five times of reusability. The ICP analysis showed the very low Pd and Cr metals leaching, representing high stability and applicability of this catalyst in Pd coupling reactions.
- Niknam, Esmaeil,Panahi, Farhad,Khalafi-Nezhad, Ali
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supporting information
(2021/01/12)
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- Ring-in-ring(s) complexes exhibiting tunable multicolor photoluminescence
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One ring threaded by two other rings to form a non-intertwined ternary ring-in-rings motif is a challenging task in noncovalent synthesis. Constructing multicolor photoluminescence systems with tunable properties is also a fundamental research goal, which
- Wu, Huang,Wang, Yu,Jones, Leighton O.,Liu, Wenqi,Song, Bo,Cui, Yunpeng,Cai, Kang,Zhang, Long,Shen, Dengke,Chen, Xiao-Yang,Jiao, Yang,Stern, Charlotte L.,Li, Xiaopeng,Schatz, George C.,Fraser Stoddart
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supporting information
p. 16849 - 16860
(2020/11/09)
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- A pyridine chain conjugated system polymer derivatives and its preparation method and application (by machine translation)
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The invention discloses a pyridine chain conjugated system polymer derivatives and its preparation method and application, relates to the field of organic synthetic technology. The compounds of the invention have the general formula 1, formula 2, formula 3 or formula 4 four kinds of structure; wherein R1 To bromine, methyl, tert-butyl, methoxy, ester or amide group; m is 2 or 3; formula 2 R in the2 Bromo, ester group, amido group or a carboxyl group; R3 Is hydrogen, fluoro, methyl, methoxy, ester or amide; formula 3 or formula 4 in the X is a carbon atom or a nitrogen atom; R4 Hydrogen, methyl, fluorine, chlorine, bromine or nitro; Y is a carbon atom or a nitrogen atom; Z is imino or oxygen atom. The invention synthetic compounds of rotenone induced PC12 cell injury has obvious protection functions, and to α - Syn protein aggregation and fibrosis has obvious inhibition, statistical significance, may be further developed to be used for the treatment of Parkinson's drug; the general formula 1 - general formula 4 are respectively: (by machine translation)
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Paragraph 0181-0186
(2019/06/07)
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- Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation
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Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.
- Liu, Hao,Chen, Li,Zhou, Fei,Zhang, Yun-Xiao,Xu, Ji,Xu, Meng,Bai, Su-Ping
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supporting information
p. 3089 - 3096
(2019/06/14)
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- A Dynamic Tetracationic Macrocycle Exhibiting Photoswitchable Molecular Encapsulation
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Designing macrocycles with appropriate molecular recognition features that allow for the integration of suitable external stimuli to control host-guest processes is a challenging endeavor which enables molecular containers to solubilize, stabilize, and separate chemical entities in an externally controllable manner. Herein, we introduce photo- and thermal-responsive elements into a semi-rigid tetracationic cyclophane, OPVEx2Box4+, that is composed of oligo(p-phenylenevinylene) pyridinium units and the biphenylene-bridged 4,4-bipyridinium extended viologens and adopts a rectangle-like geometry. It transpires that when the photoactive oligo(p-phenylenevinylene) pyridinium unit is incorporated in a macrocyclic scaffold, its reversibility is dramatically improved, and the configurations of the cyclophane can go back and forth between (EE)- and (EZ)-isomers upon alternating blue light irradiation and heating. When the macrocycle is found in its (EE)-configuration, it is capable of binding various π-electron-rich guests - e.g., anthracene and perylene - as well as π-electron-deficient guests - e.g., 9,10-anthraquinone and 5,12-tetracenequinone - through charge-transfer and van der Waals interactions. When irradiated with blue light, the (EE)-isomer of the cyclophane can be transformed successfully to the (EZ)-isomer, resulting in the switching off of the binding affinity for guest molecules, which are bound once again upon heating. The use of light and heat as external stimuli to control host-guest interactions involving a multi-responsive host and various guests provides us with a new opportunity to design and construct more-advanced molecular switches and machines.
- Wu, Huang,Chen, Yong,Zhang, Long,Anamimoghadam, Ommid,Shen, Dengke,Liu, Zhichang,Cai, Kang,Pezzato, Cristian,Stern, Charlotte L.,Liu, Yu,Stoddart, J. Fraser
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supporting information
p. 1280 - 1289
(2019/01/14)
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- Solvent-Mediated Synthesis of Cyclobutane Isomers in a Photoactive Cadmium(II) Porous Coordination Polymer
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Photochemical [2+2] cycloaddition of 1,4-bis[2-(4-pyridyl)ethenyl]benzene, carried out in a CdII porous coordination polymer (PCP), produces different isomeric products depending on the guest solvent present in the PCP during irradiation. The n
- Claassens, Isabella E.,Nikolayenko, Varvara I.,Haynes, Delia A.,Barbour, Leonard J.
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supporting information
p. 15563 - 15566
(2018/10/31)
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- Electrochromic compounds, electrochromic composition, and a display element
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PROBLEM TO BE SOLVED: To provide an electrochromic compound and electrochromic composition which show sharp light absorption spectral characteristics in color development, and present yellow based, cyan based, and black based color developments, and to provide a display element using the electrochromic compound or electrochromic composition. SOLUTION: The electrochromic compound is represented by formula (1). In the formula (1), X1, X2, X3, and X4each independently denote a hydrogen atom or a monovalent substituent, n denotes the integer of 1 to 6, Rs each independently denote a monovalent substituent, and Ar denotes a benzene ring which may have a substituent when n is from 1 to 5, and only a benzene ring when n is 6, and A-denotes a monovalent anion. COPYRIGHT: (C)2011,JPOandINPIT
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Paragraph 0136-0137
(2016/10/10)
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- Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds
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Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. However, these compounds are relatively hydrophobic, which likely limits their in vivo potential. Based on their structures, we hypothesized that less hydrophobic bis-pyridylethenylbenzenes may also label amyloid. We synthesized several bis-pyridylethenylbenzenes and tested whether these compounds indeed display improved solubility and lower Log?P values, and studied their fluorescent properties and Aβ binding characteristics. Bis-pyridylethenylbenzenes showed a clear affinity for Aβ plaques on both human and murine AD brain sections. Competitive binding experiments suggested a different binding site than Chrysamine G, a well-known stain for amyloid. With a Log?P value between 3 and 5, most bis-pyridylethenylbenzenes were able to enter the brain and label murine amyloid in vivo with the bis(4-pyridylethenyl)benzenes showing the most favorable characteristics. In conclusion, the presented results suggest that bis-pyridylethenylbenzene may serve as a novel backbone for amyloid imaging agents.
- Nabuurs, Rob J.A.,Kapoerchan, Varsha V.,Metaxas, Athanasios,Hafith, Sarah,de Backer, Maaike,Welling, Mick M.,Jiskoot, Wim,van den Nieuwendijk, Adrianus M.C.H.,Windhorst, Albert D.,Overkleeft, Herman S.,van Buchem, Mark A.,Overhand, Mark,van der Weerd, Louise
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p. 6139 - 6148
(2016/11/30)
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- Redox-active structures and devices utilizing the same
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A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.
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Page/Page column 25; 26
(2016/05/09)
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- Controlled formation of chiral networks and their reversible chiroptical switching behaviour by UV/microwave irradiation
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A 3D coordination polymer {[Cd(L1)(L2)]2}n (1) spontaneously resolves into enantiomorphic crystals of 1P and 1M without any chiral source. Bulk quantities of 1P and 1M can be predictably and reliably obtained by
- Hu, Fei-Long,Wang, Hui-Fang,Guo, Dong,Zhang, Hui,Lang, Jian-Ping,Beves, Jonathon E.
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supporting information
p. 7990 - 7993
(2016/07/06)
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- IMAGING LIGANDS
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Compound or a salt or solvate thereof for use as an imaging ligand for the detection of aggregated amyloid-β or for use as a medicament according to the formula (I): wherein R1 and R3 may be the same or different optionally substituted pyridinyl group and wherein R2 is hydrogen or a substituent group comprising at least an oxygen atom or a fluor atom.
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Page/Page column 8
(2013/05/22)
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- Controlled stacking and unstacking of peripheral chlorophyll units drives the spring-like contraction and expansion of a semi-artificial helical polymer
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Developing new strategies for controlling polymer conformations through precise molecular recognition can potentially generate a machine-like motion that is dependent on molecular information - an important process for the preparation of new intelligent nanomaterials (e.g., polymer-based nanomachines) in the field bordering between polymer chemistry and conventional supramolecular sciences. Herein, we propose a strategy to endow a helical polymer chain with dynamic spring-like (contraction/expansion) motion through the one-dimensional self-assembly (aggregation/disaggregation) of peripheral amphiphilic molecules. In this developing system, we employed a semi-artificial helical polysaccharide presenting peripheral amphiphilic chlorophyll units as a power device that undergoes contractive motion in aqueous media, driven by strong π-π interactions of its chlorophyll units or by cooperative molecular recognition of bipyridyl-type ligands through pairs of chlorophyll units, thereby converting molecular information into the regulated motion of a spring. In addition, this system also undergoes expansive motion through coordination of pyridine. We anticipate that this strategy will be applicable (when combined with the established wrapping chemistry of the helical polysaccharide) to the development of, for example, drug carriers (e.g., nano-syringes), actuators (stimuli-responsive films), and directional transporters (nano-railways), thereby extending the frontiers of supramolecular science. Copyright
- Numata, Munenori,Kinoshita, Daiki,Hirose, Naoya,Kozawa, Tomohiro,Tamiaki, Hitoshi,Kikkawa, Yoshihiro,Kanesato, Masatoshi
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supporting information
p. 1592 - 1598
(2013/03/14)
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- Synthesis, characterization and property studies on a dinuclear copper(II) complex with dipyridine derivate and acetylacetone
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A dinuclear copper(II) complex of [Cu2(aceace) 4(dipyph)] [aceace = acetylacetone, dipyph = 1,4-di(4-pyridylethene- 2-yl-)benzene] has been synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction. It crystallizes in the monoclinic system, space group P21/c, with lattice parameters a = 7.9584(16) A, b = 18.594(4) A, c = 15.063(4) A, β = 120.97(2)° and Mr = 807.85 (C40H44Cu2N2O8), Z = 2. Each of the Cu2+ ion adopts a square pyramid geometry and coordinates with four oxygen atoms from two aceace ligands and one nitrogen atom from dipyph bidentate ligand. Magnetic measurement shows that the Weiss constant and Curie constant for the title compound are -0.22 K and 0.1154 emu·K/mol, respectively. Thermal stability data indicate that the title complex undergoes two steps decomposition and the residue is Cu 2O4. In the potential range of -1.5 ~ 0.8 V, the title complex represents an irreversible electrochemical process.
- Zhao, Pu Su,Guo, Zhi Yan,Sui, Jing,Wang, Jing,Jian, Fang Fang
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scheme or table
p. 49 - 52
(2011/11/06)
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- Synthesis, optical, and thermal properties of conjugated, bispyridyl and tetrapyridyl compounds by Knoevenagel reaction
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A series of conjugated, bispyridyl and tetrapyridyl compounds were synthesized from either terephthalaldehyde or isophthalaldehyde and activated pyridyl compounds by Knoevenagel reaction on heating in acetic anhydride in presence of acetic acid and their
- Bhowmik, Pradip K.,Nedeltchev, Alexi K.,Han, Haesook
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p. 5383 - 5387
(2008/02/10)
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- Design of ??-conjugated organic materials for one-dimensional energy transport in nanochannels
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Various end-substituted distyrylbenzenes have been synthesized to serve as guest molecules in inclusion compounds to promote efficient energy transport along one-dimensional channels. Their optical and photophysical properties have been characterized at b
- Sancho-Garciì?a, Juan Carlos,Breì?das, Jean-Luc,Beljonne, David,Cornil, Jeì?roì?me,Martiì?nez-Aì?lvarez, Roberto,Hanack, Michael,Poulsen, Lars,Gierschner, Johannes,Mack, Hans-Georg,Egelhaaf, Hans-Joachim,Oelkrug, Dieter
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p. 4872 - 4880
(2008/03/14)
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- Polymers and oligomers, their synthesis, and electronic devices incorporating same
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The invention relates to polymers and oligomers, methods of their synthesis, and electronic devices comprising them.
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Page/Page column 10
(2008/06/13)
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- Acidochromism of C2-symmetrical aza-analogues of 1,4-distyrylbenzene
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A series of C2-symmetrical aza-analogous 1,4-distyrylbenzenes were synthesised via two-fold PO-activated olefinations or Heck reactions. Pyridine, pyrimidine and quinoline were used as terminal rings, and the 2,5-positions of the central benzen
- Detert, Heiner,Sadovski, Oleg,Sugiono, Erli
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p. 1046 - 1050
(2007/10/03)
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- Synthesis of novel linear exo-bidentate bispyridine ligands and their complexes with silver(I) tetrafluoroborate
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Novel exo-bidentate ligands containing two γ-pyridyl fragments and their complexes with silver(I) tetrafluoroborate were synthesized.
- Vatsadze,Nuriev,Chernikov,Zyk
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p. 1957 - 1958
(2007/10/03)
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- Metal-Metal Interactions Across Symmetrical Bipyridyl Bridging Ligands in Binuclear Seventeen-electron Molybdenum Complexes
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A series of 17-electron mononuclear complexes and their binuclear counterparts 2(μ-X)> benzene (bpeb) or 1,4-bis(4-pyridyl)benzene (bpb)> have been prepared.Electrochemical studies show that the reduction potentials of the mononuclear complexes are sensitive to the degree of unsaturation in the monodentate ligand X, whereas the oxidation potentials are virtually constant.This suggests that the redox orbital involved in the reductions have considerable ligand-based character whereas the oxidations are more strongly metal-centred.This is supported by the electrochemical properties of the binuclear complexes, where the oxidation potentials are in every case coincident but the splitting between the reduction potentials of the equivalent molybdenum centres varies from 0.16 V (X = bpeb) to 0.56 V (X = bpac).By contrast the splitting of the redox potentials of pentaammineruthenium(II) fragments at either end of 'extended' 4,4'-bipyridine analogues of this type is an order of magnitude smaller.This strong interaction between moieties is in part due to a planar conformation of the bridging ligands, even when they are in principle capable of free rotation, since changing the bridging ligand from 4,4'-bipyridine to 3,3'-dmbipy (which cannot be planar due to the steric effects of the methyl groups) results in a decrease in the splitting of the reduction potentials from 0.77 to 0.38 V.The EPR spectra of the binuclear complexes all show that the two unpaired electrons (one at each 17-electron molybdenum centre) are in fast exchange across the bridging ligand at room temperature.
- Das, Amitava,Maher, John P.,McCleverty, Jon A.,Badiola, Jon A. Navas,Ward, Michael D.
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p. 681 - 686
(2007/10/02)
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