PYRIDOXAL AMINOGUANIDINE DERIVATIVES AND THEIR SALTS AND PRODUCTION METHOD THEREOF
PROBLEM TO BE SOLVED: To provide compounds which are good in absorptivity on oral administration, serve as hypoglycemic agents with high safety and are useful as inhibitors for AGE formation reactions and their production method. SOLUTION: A method of producing pyridoxal/aminoguanidine derivatives and their salts having a structure with the amino group of pyridine derivatives of formula (V) substituted with another group comprises reacting pyridoxal with one of 1-amino-3-propyl guanidine hydroiodide, 4-methyl-S-methylisothiosemicarbazide hydroiodide, 3-methylisosemicarbazide hydrochloride and morpholine-4-carboxyimide hydrazide hydroiodide. COPYRIGHT: (C)2015,JPO&INPIT
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Paragraph 0033; 0034
(2019/01/04)
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