SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS
The present invention provides novel compounds and methods useful for treating transglutaminase associated disorders such as celiac spru, Alzheimer's disease and Huntington's disease. Certain compounds of the invention are tissue transglutaminase inhibito
-
Page/Page column 89
(2010/11/08)
Structure-activity relationship study of novel tissue transglutaminase inhibitors
Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative
Duval, Eric,Case, April,Stein, Ross L.,Cuny, Gregory D.
p. 1885 - 1889
(2007/10/03)
More Articles about upstream products of 312946-37-5