- Fine-Tuned Photoactive and Interconnection Layers for Achieving over 13% Efficiency in a Fullerene-Free Tandem Organic Solar Cell
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Fabricating organic solar cells (OSCs) with a tandem structure has been considered an effective method to overcome the limited light absorption spectra of organic photovoltaic materials. Currently, the most efficient tandem OSCs are fabricated by adopting
- Cui, Yong,Yao, Huifeng,Gao, Bowei,Qin, Yunpeng,Zhang, Shaoqing,Yang, Bei,He, Chang,Xu, Bowei,Hou, Jianhui
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Read Online
- Impact of donor–acceptor alternation on optical power limiting behavior of H–Shaped thiophene–imidazo[2,1-b] [1,3,4]thiadiazole flanked conjugated oligomers
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A new series of four D–A–D configured conjugated oligomers with H–type structure, possessing two thiophene–imidazo [2,1-b][1,3,4]thiadiazole branches and thiophene (TIT), thiophene–1,3,4-oxadiazole–thiophene (TITO), thiazolo [5,4-d]thiazole (TITz), phenyl
- Kakekochi, Viprabha,Nikhil P,Chandrasekharan, Keloth,Kumar D, Udaya
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- Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent
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The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.
- Yang, Qi-Liang,Wang, Xiang-Yang,Wang, Tong-Lin,Yang, Xiang,Liu, Dong,Tong, Xiaofeng,Wu, Xin-Yan,Mei, Tian-Sheng
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supporting information
p. 2645 - 2649
(2019/04/17)
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- Pd(II)-Catalyzed asymmetric oxidative annulation of N-alkoxyheteroaryl amides and 1,3-dienes
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The first Pd(II)-catalyzed asymmetric oxidative annulation of N-alkoxyaryl amides and 1,3-dienes is reported, which features particular applicability for quick assembly of different types of chiral heterocycles with high yields and enantioselectivities. A novel chiral pyridine-oxazoline bearing a methoxyl group at the C-5 position and a gem-dimethyl group on the oxazoline moiety was found to be crucial for conversion.
- Zhang, Tao,Shen, Hong-Cheng,Xu, Jia-Cheng,Fan, Tao,Han, Zhi-Yong,Gong, Liu-Zhu
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supporting information
p. 2048 - 2051
(2019/03/29)
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- 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
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Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an a
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Paragraph 0842; 0843
(2016/10/31)
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- Directing Group-Assisted Copper(II)-Catalyzed ortho-Carbonylation to Benzamide using 2,2′-Azobisisobutyronitrile (AIBN)
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An efficient copper-catalyzed regioselective C—H bond carbonylation of benzamides has been developed using 2,2′-azobisisobutyronitrile (AIBN) as traceless cyanating agent. The non-toxic and readily available AIBN was used for the carbonylative cyclization
- Khan, Bhuttu,Khan, Afsar Ali,Kant, Ruchir,Koley, Dipankar
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supporting information
p. 3753 - 3758
(2016/12/16)
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- Nickel Catalysis Enables Oxidative C(sp2)–H/C(sp2)–H Cross-Coupling Reactions between Two Heteroarenes
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Nickel can be used to promote oxidative C(sp2)?H/C(sp2)?H cross-coupling between two heteroarenes. The reaction scope can be extended to aromatic carboxamides as the coupling partner. The reaction exhibits high functional-group compatibility and broad substrate scope. The silver oxidant can be recycled to reduce costs and waste, which is very useful for practical applications.
- Cheng, Yangyang,Wu, Yimin,Tan, Guangyin,You, Jingsong
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supporting information
p. 12275 - 12279
(2016/10/13)
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- PROCESS FOR THE SYNTHESIS OF SUBSTITUTED GAMMA LACTAMS
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The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like.
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Paragraph 0057-0058
(2014/03/24)
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- PROCESS FOR THE SYNTHESIS OF SUBSTITUTED GAMMA LACTAMS
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The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like.
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Page/Page column 13
(2014/03/25)
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- 3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents
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Small molecules with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guérin (BCG), among which HT1171 was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one molecules in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one compound 4n was found to be the most active with a lowest MIC90 value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound 4n displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.
- Yang, Jianzhong,Pi, Weiyi,Xiong, Li,Ang, Wei,Yang, Tao,He, Jun,Liu, Yuanyuan,Chang, Ying,Ye, Weiwei,Wang, Zhenling,Luo, Youfu,Wei, Yuquan
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supporting information
p. 1424 - 1427
(2013/03/14)
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- Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors
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Human African trypanosomiasis (HAT) is one of the most neglected diseases in the tropic regions, which is fatal if not treated in time. There is an urgent need for new therapeutics, especially those in new chemical classes. Leucyl-tRNA synthetase (LeuRS) has been paid much attention as a recently clinically validated antimicrobial target. Our group has previously reported T. brucei LeuRS (TbLeuRS) inhibitors, including benzoxaboroles targeting the editing site and pyrrolinones targeting the synthetic site. Here we report the discovery of N-(4-sulfamoylphenyl)thioureas as a new class of TbLeuRS inhibitors. The R1 and R2 groups, reminiscent of the leucyl and adenyl regions of aa-AMP and aa-AMS, were optimized to result in a significant 13-fold increase of inhibitory activity (compound 19, IC 50 = 13.7 μM). Aided by ligand-protein docking, the 1,3-substitution at the central phenyl ring was predicted and proved to give significantly improved activity (59, IC50 = 1.1 μM). This work provided a new scaffold for the exploration of novel inhibitors against TbLeuRS, which may become potential therapeutics for the treatment of HAT.
- Zhang, Fenglong,Du, Jin,Wang, Qing,Hu, Qinghua,Zhang, Jiong,Ding, Dazhong,Zhao, Yaxue,Yang, Fei,Wang, Enduo,Zhou, Huchen
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p. 5310 - 5324
(2013/08/23)
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- Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs
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6,7-Methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-ones and their isosteric compounds were synthesized and evaluated for anticancer activity. Structure-activity relationships (SAR) of these compounds were established. Among all tested compounds, 6,7-methylenedioxy-2-(5-methylselenophen-2-yl)quinolin-4-one (4d) was found to be the most promising anticancer agent. In screening against NCI's 60 human tumor cell line panel, 4d exhibited highly selective and potent inhibitory activity against MDA-MB-435 melanoma. Furthermore, the results of COMPARE analysis suggested that 4d is an antimitotic agent with a different mechanism of action from the conventional antimitotic agents, such as colchicine, vinca alkaloids and paclitaxel. Therefore, 4d was identified as a new lead compound that merits further optimization.
- Chen, Chien-Ting,Hsu, Mei-Hua,Cheng, Yung-Yi,Liu, Chin-Yu,Chou, Li-Chen,Huang, Li-Jiau,Wu, Tian-Shung,Yang, Xiaoming,Lee, Kuo-Hsiung,Kuo, Sheng-Chu
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experimental part
p. 6046 - 6056
(2012/02/05)
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- THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS
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Compounds of the formula (I) are provided: Fomula (I) wherein X, Y, R1, R2 and R3 are as defined in the specification. The compounds may be useful in the treatment of various diseases and conditions, in particular prion diseases.
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Page/Page column 44
(2008/12/07)
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- ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS
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The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.
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Page/Page column 32-33
(2008/12/07)
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- Library synthesis and screening: 2,4-Diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics
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Transmissible spongiform encephalopathies (TSEs) are a family of invariably fatal neurodegenerative disorders for which no effective therapeutics are currently available. In this paper, we report on the synthesis and screening of a small library of 2,4-diphenylthiazol-5-ylamine and 2,4-diphenyloxazol-5- ylamine derivatives as potential novel prion disease therapeutics. Various synthetic strategies were investigated, including a novel phosgene-mediated cyclization of 2-N-benzoylphenylglycinonitrile, and a total of 45 compounds were synthesized. Library members were tested for both binding to prion protein (PrPC) using the surface plasmon resonance technique and for inhibition of PrPSc formation in persistently infected SMB cells. Of the compounds prepared, 15 were found to bind to human PrPC and six showed inhibition of PrPSc formation, displaying EC50s between 1.5 and 20 μM.
- Heal, William,Thompson, Mark J.,Mutter, Roger,Cope, Hannah,Louth, Jenny C.,Chen, Beining
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p. 1347 - 1353
(2007/10/03)
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- Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles
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Some new 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives have been synthesized by reacting 5-amino-2-(benzyl/p-chlorobenzyl)benzoxazoles with appropriate carboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR, 1H NMR and MASS spectral data. In vitro antimicrobial activities of the compounds were investigated using twofold serial dilution technique against different two Gram-positive, two Gram-negative bacteria and three Candida spp. in comparison with standard drugs. Microbiological results indicated that the newly synthesized 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives (3-12) possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Especially, with an MIC value of 6.25 μg/ml, 2-(p-chlorophenyl)-5-[(2,5-dimethylphenyl)carbonylamino]benzoxazole 4 displayed the same activity against Candida albicans as the standard drug clotrimazole.
- Tekiner-Gulbas, Betul,Temiz-Arpaci, Ozlem,Yildiz, Ilkay,Altanlar, Nurten
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p. 1293 - 1299
(2008/03/28)
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- N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types
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A range of N-glycosyl-thiophene-2-carboxamides, including a 6H-thieno[2,3-c]pyridin-7-one and a bivalent compound, have been synthesised and assayed for their effects on DNA synthesis in bovine aortic endothelial cells or on the growth of synoviocytes. Per-O-acetylated analogues of the glycoconjugates were significantly more effective inhibitors when compared to their corresponding non-acetylated analogues, indicating that the lower potency observed for hydroxylated derivatives is due to less efficient transport of these compounds across the cell membrane. Thiophene-2-carboxamide was inactive as an inhibitor of bFGF induced proliferation, confirming the requirement of the carbohydrate residue for the observed biological properties. Glucose, mannose, galactose and 2-amino-2-deoxy-glucose analogues were active as were a variety of substituted thiophene derivatives; the 6H-thieno[2,3-c]pyridin-7-one conjugate was inactive. Conformational analysis of the title compounds was investigated. X-ray crystal structural analysis of four N-glucosyl-thiophene-2-carboxamides showed that the pyranose rings adopted the expected 4C1 conformations and that Z-anti structures were predominant (H1-C1-N-H anomeric torsion angle varied from -168.2° to -175.0°) and that the carbonyl oxygen and sulfur of the thiophene adopted an s-cis conformation in three of the isomers. In a crystal structure of a 3-alkynyl derivative, the hydrogen atom of the NH group was directed toward the acetylene group. The distance between the hydrogen atom and acetylene carbons and angles between nitrogen, hydrogen and carbon atoms were consistent with hydrogen bonding and this was supported by IR and NMR spectroscopic studies. The geometries of thiophene-2-carboxamides were explored by density functional theory (DFT) and Moller-Plesset (MP2) calculations and the s-cis conformer of thiophene-2-carboxamide was found to be more stable than its s-trans isomer by 0.83 kcal mol-1. The s-cis conformer of 3-ethynyl-thiophene-2-carboxamide was 5.32 kcal mol-1 more stable than the s-trans isomer. The larger stabilisation for the s-cis conformer in the 3-alkynyl derivatives is explained to be due to a moderate hydrogen bonding interaction between the alkyne and NH group.
- Rawe, Sarah L.,Doyle, Dearbhla,Zaric, Violeta,Rozas, Isabel,McMahon, Kevin,Tosin, Manuela,Bunz, Helge Mueller,Murphy, Evelyn P.,O' Boyle, Kathy M.,Murphy, Paul V.
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p. 1370 - 1390
(2007/10/03)
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- Benzoxazole carboxamides for treating CINV and IBS-D
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Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.
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Page/Page column 62
(2008/06/13)
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- Ramoplanin derivatives possessing antibacterial activity
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Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
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Page/Page column 54
(2010/11/23)
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- Synthesis, characterization, and structure of cyclopenta[c]thiophenes and their manganese complexes
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1,3-Diaryl-4H-cyclopenta[c]thiophenes are efficiently prepared from 1,2-diaroylcyclopentadienes by use of Lawesson's reagent. η5-Cyclopenta[c]thienyl complexes, [Mn(η5-SC7H3-1,3-R2)(CO)3] (
- Snyder, Chad A.,Selegue, John P.,Tice, Nathan C.,Wallace, Chad E.,Blankenbuehler, Mark T.,Parkin, Sean,Allen, Keith D. E.,Beck, Ryan T.
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p. 15010 - 15011
(2007/10/03)
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- Benzothiazole derivatives with activity as adenosine receptor ligands
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The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
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- α2 adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes
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A series of imidazolylmethylthiophenes has been prepared and evaluated as ligands for the α2 adrenoceptor. These compounds were tested in two animal models that are predictive of analgesic activity in humans. The 3-thienyl compounds were generally the most potent, particularly those with substitution in the 4-position. A subset of the most active compounds was further evaluated for adverse cardiovascular effects in the anesthetized rat model. In addition to excellent binding at the α2D adrenoceptor, the 4-bromo analogues 20e and 21e were very active in the rat abdominal irritant test (RAIT) with ED50 doses of 0.38 and 0.31 mg/kg, respectively. We constructed a pharmacophore model based on the biological activity of the present series, dexmedetomidine (1), and conformationally restrained analogues 3 and 4.
- Boyd,Rasmussen,Press,Raffa,Codd,Connelly,Li,Martinez,Lewis,Almond,Reitz
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p. 863 - 872
(2007/10/03)
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- N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety
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We previously reported the identification of (2S)-((2- benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-phenyloxazol-4- yl)ethoxy]phenyl}propanoic acid (2) (PPARγ pK(i) = 8.94, PPARγ pEC50 = 9.47) as a potent and selective PPARγ agonist. We now report the expanded structure-activity relationship around the phenyl alkyl ether moiety by pursuing both a classical medicinal chemistry approach and a solid-phase chemistry approach for analogue synthesis. The solution-phase strategy focused on evaluating the effects of oxazole and phenyl ring replacements of the 2-(5-methyl-2-phenyloxazol-4-yl)ethyl side chain of 2 with several replacements providing potent and selective PPARγ agonists with improved aqueous solubility. Specifically, replacement of the phenyl ring of the phenyloxazole moiety with a 4-pyridyl group to give 2(S)-((2- benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-pyridin-4-yloxazol-4- yl)ethoxy]phenyl}propionic acid (16) (PPARγ pK(i) = 8.85, PPARγ pEC50 = 8.74) or a 4-methylpiperazine to give 2(S)-((2-benzoylphenyl)amino)-3-(4- {2-[5-methyl-2-(4-methylpiperazin-1-yl)thiazol-4-yl]ethoxy}phenyl)propionic acid (24) (PPARγ pK(i) = 8.66, PPARγ pEC50 = 8.89) provided two potent and selective PPARγ agonists with increased solubility in pH 7.4 phosphate buffer and simulated gastric fluid as compared to 2. The second strategy took advantage of the speed and ease of parallel solid-phase analogue synthesis to generate a more diverse set of phenyl alkyl ethers which led to the identification of a number of novel, high-affinity PPARγ ligands (PPARγ pK(i)'s 6.98-8.03). The combined structure-activity data derived from the two strategies provide valuable insight on the requirements for PPARγ binding, functional activity, selectivity, and aqueous solubility.
- Collins, Jon L.,Blanchard, Steven G.,Boswell, G. Evan,Charifson, Paul S.,Cobb, Jeff E.,Henke, Brad R.,Hull-Ryde, Emily A.,Kazmierski, Wieslaw M.,Lake, Debra H.,Leesnitzer, Lisa M.,Lehmann, Jürgen,Lenhard, James M.,Orband-Miller, Lisa A.,Gray-Nunez, Yolanda,Parks, Derek J.,Plunkett, Kelli D.,Tong, Wei-Qin
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p. 5037 - 5054
(2007/10/03)
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- Retinoids as potential chemotherapeutic agents. Synthesis, cytostatic and differentiating activities of new heterocyclic analogues of retinoic acid
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The synthesis of a new class of heterocyclic analogues of retinoids and their cytostatic and differentiating activities against HL-60 cells are reported. Several of the tested compounds (i.e. 7c, 7e, and 7f) were markedly more cytostatic to HL-60 than oth
- Manfredini,Simoni,Caminiti,Vertuani,Invidiata,Moscato,Hatse,De Clercq,Balzarini
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p. 291 - 304
(2007/10/03)
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- Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands
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2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2- position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2-position showed high binding affinity and in vivo activity. In the imidazo[4,5-c]quinoline series, substitution at the 6-position decreased or abolished activity. Most derivatives with an unsubstituted isoxazolyl group showed antagonist or inverse agonist activity except for the 7-halo analogues, which exhibited agonist activity. On the other hand, 5-methylisoxazol-3-yl or 3-methylisoxazol-5-yl derivatives generally exhibited agonist activity. A similar substitution effect on the isoxazole moiety was observed in the imidazopyridines fused with a nonaromatic ring. From the detailed pharmacological evaluation, S-8510, 2- (3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine monophosphate, possessing weak inverse agonist activity was selected as a therapeutic candidate for the treatment of some symptoms of senile dementia.
- Takada, Susumu,Sasatani, Takashi,Chomei, Nobuo,Adachi, Makoto,Fujishita, Toshio,Eigyo, Masami,Murata, Shunji,Kawasaki, Kazuo,Matsushita, Akira
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p. 2844 - 2851
(2007/10/03)
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- Liquid Crystalline Compounds in the Thiophene Series, Part 11. Liquid Crystalline Thiophene Carboxylic Esters
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The new series of ten 4,4'-bis(5-alkyl-2-thienylcarbonyloxy)azobenzenes (2a-2j) and ten 2,5-bis(5-alkyl-2-thienylcarbonyloxy)toluenes (3a-3j) were prepared.These, as yet unknown esters were characterized in relation to their structures by elemental analyses, IR, UV, 1H NMR spectra and MS.The azobenzene-esters 2a-2j which form liquid crystalline phases were studied by microscopy under polarized light and DSC (differential scanning calorimetry).Through the observation of the optical textures nematic phases were monitored.Only 2j has an additional smectic phase; 2h and 2i form monotropic smectic phases during cooling.The toluene-esters 3a-3j do not form liquid crystalline phases. - Keywords: Liquid Crystalline Thiophene Derivatives; Thiophene Carboxylic Esters; Mesogenic Groups; Liquid Crystalline Esters; Liquid Crystalline Azobenzene Derivatives
- Kossmehl, Gerhard,Hirsch, Barbara
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p. 1265 - 1274
(2007/10/03)
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- Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances
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Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula STR1 in which Y=NH, O or S when m=1; Y=N when m=2; m=1 or 2; l=0 or 4; R=H, C1-4 alkyl, Cl, Br, CF3, CH2 OCOCH3, or OCH2 -Ph; R1 =H, alkaline metal or alkaline earth metal, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Such derivatives possess high antiallergic activity.
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- Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances
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Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula (I): in which, Y = NH, O or S when m = 1;, Y = N when m = 2;, m = 1 or 2;, l = 0 or 4;, R = H, C1 4 alkyl, Cl, Br, CF3, CH2OCOCH3, or OCH2-Ph;, R1 = H, alkaline metal or alkaline earth metal;, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Said derivatives possess high antiallergic activity.
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- SIDE CHAIN POLYMERS CONTAINING 4-(5-ALKYLATED 2-THIENYLCARBONYLOXY)BENZOIC ACID
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The synthesis of a series of 4-(5-substituted 2-thienylcarbonyloxy)benzoic acid is reported.Their mesomorphic behaviour is investigated by DSC and polarizing microscopy, indicating schlieren textures.Esters of the above compounds with ω-alkenyl substituents are reacted with poly(hydrogenmethylsiloxane) to give alkylated side chain poly(methylsiloxane)s, which are investigated by the same methods.The alkylated poly(methylsiloxane)s with long spacers have schlieren textures.
- Kossmehl, Gerhard,Pithart, Cornelia
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p. 167 - 170
(2007/10/02)
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- Liquid Crystalline Compounds in the Thiophene Series. 1. Liquid Crystalline Thiophene Carboxylic Esters
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Carboxylic esters have been prepared from 5-alkyl-2-thiophenecarboxylic acid and hydrochinone, biphenol, respectively cholesterol as well as one ester from 2,5-thiophene dicarboxylic acid and p-ethylphenol.Only the esters from biphenol respectively cholesterol have liquid crystalline phases. - Keywords: Liquid Crystalline Thiophene Derivatives, Thiophene Carboxylic Esters
- Kossmehl, Gerhard,Budwill, Detlev
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p. 1669 - 1677
(2007/10/02)
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