- MODIFIED PROTEINS AND PROTEIN DEGRADERS
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Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
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- DIFLUOROMETHYLENE COMPOUND
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The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.
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Paragraph 0909; 0910
(2015/06/16)
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- NOVEL COMPOUNDS
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A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R1 is H, C1-6alkyl, - C(A)D, C3-8cycloalkyl, aryl, het, aryl-C1-4alkyl or het-C1-4/sub
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Page/Page column 48
(2008/06/13)
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- Palladium-catalyzed oxidative activation of arylcyclopropanes
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(Diagram presented) Palladium chloride-catalyzed intramolecular activation of electroneutral cyclopropane derivatives results in cleavage of the cyclopropane ring followed by formation of heterocyclic derivatives. Phenols, carboxylic acids, and amide groups were considered as substituents ortho to the cyclopropane ring in this catalytic activation chemistry. The regioselectivity observed in the case of amide-containing substrates was different from that of carboxylic acid-containing substrates, ruling out simple cyclopropane isomerization followed by a Wacker oxidation as the mechanistic pathway.
- He, Zhi,Yudin, Andrei K.
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p. 5829 - 5832
(2007/10/03)
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- 2-Cyclopropylbenzoic acids in the synthesis of phthalides and 3,4-dihydroisocoumarins
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2-Cyclopropylbenzoic acids, under the action of strong protic acids (FSO3H, H2SO4), are convened to 3-ethylphthalidium ions. In solutions in these inorganic acids, the 3-ethylphthalidium ions are isomerized to 3-methyl-3,4
- Mochalov,Fedotov,Kutateladze,Trofimova,Shabarov,Zefirov
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p. 288 - 293
(2007/10/03)
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