- Selective synthesis of 1,6-anhydro-β-D-mannopyranose and -mannofuranose using microwave-assisted heating
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The dehydration of D-mannose and the demethanolization of methyl-α-D-mannopyranoside (MαMP) or methyl-α-D- mannofuranoside (MαMF) were examined using microwave-assisted heating for a 3-min irradiation at temperature from 120 to 280 °C in ordinary or dry sulfolane without any catalyst. The microwave-assisted heating of MαMP and MαMF smoothly proceeded to selectively afford the anhydromannoses, 1,6-anhydro-β-D-mannopyranose (AMP) and 1,6-anhydro-β-D-mannofuranose (AMF), respectively, in high yields. For MαMP in ordinary sulfolane at 240 °C, AMP was selectively obtained in the AMF:AMP ratio of 4:96, whereas AMF was the major product at the AMF:AMP ratio of 97:3 from MαMF in dry sulfolane at 220 °C.
- Hoai, Nguyen To,Sasaki, Akiyoshi,Sasaki, Masahide,Kaga, Harumi,Kakuchi, Toyoji,Satoh, Toshifumi
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experimental part
p. 1747 - 1751
(2011/12/02)
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