- Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors
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A series of novel phenol ether derivatives were designed, synthesized, and evaluated as non-covalent proteasome inhibitors. Most compounds exhibited moderate to excellent proteasome inhibitory activity. In particular, compound 18x proved to be the most po
- Yu, Jianjun,Xu, Lei,Hong, Duidui,Zhang, Xiaotuan,Liu, Jieyu,Li, Daqiang,Li, Jia,Zhou, Yubo,Liu, Tao
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p. 543 - 558
(2018/11/10)
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- PYRIDOPYRAZINE COMPOUNDS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
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The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, w
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- Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization
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Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.
- He, Yuwei,Cheng, Chuyu,Chen, Bin,Duan, Kun,Zhuang, Yue,Yuan, Bo,Zhang, Meisan,Zhou, Yougui,Zhou, Zihong,Su, Yu-Jun,Cao, Rihui,Qiu, Liqin
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supporting information
p. 6366 - 6369
(2015/01/16)
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- PIPERAZINYL ANTIVIRAL AGENTS
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Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
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Page/Page column 161
(2011/04/25)
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- OXINDOLE DERIVATIVES
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There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.
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Page/Page column 77
(2008/06/13)
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- Selective mono-BOC protection of diamines
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A facile route for mono-BOC protection of symmetrical and unsymmetrical diamines was developed by sequential additions of 1 mol of HCl and 1 mol of (BOC)2O followed by neutralization. Copyright Taylor & Francis Group, LLC.
- Lee, Dae Woo,Ha, Hyun-Joon,Lee, Won Koo
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p. 737 - 742
(2007/10/03)
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- Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase
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New 5-chloro-6-substituted-uracil derivatives have been prepared by microwave assisted-synthesis and tested in vitro as thymidine phosphorylase inhibitors. One of these compounds showed potent inhibitory activity, with an IC50 value in the subm
- Corelli, Federico,Botta, Maurizio,Lossani, Andrea,Pasquini, Serena,Spadari, Silvio,Focher, Federico
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p. 987 - 992
(2007/10/03)
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