- N-Trifluoromethyl Hydrazines, Indoles and Their Derivatives
-
Reported herein is the first efficient strategy to synthesize a broad range of unsymmetrical N-CF3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri- and tetra-substituted N-CF3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N-CF3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF3)-NH2 to function as a directing group in C?H functionalization is also showcased.
- Bouayad-Gervais, Samir,Scattolin, Thomas,Schoenebeck, Franziska
-
supporting information
p. 11908 - 11912
(2020/05/18)
-
- TRIAZOLE COMPOUNDS AS ANTIVIRALS
-
The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
- -
-
Paragraph 0265
(2014/01/18)
-