- Industrial preparation method of ornithine aspartate (by machine translation)
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The industrial preparation method of the ornithine ornithine aspartate according 8 - 10, pH to the present invention, has the advantages of: simplicity L - in preparation process, first high purity of the product, low content of impurities of, the product, high, safety, second and low cost, and is suitable pH for 6 - 8, industrial production, and the like. (by machine translation)
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Paragraph 0034-0053
(2020/01/12)
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- Preparation method of L-ornithine-L-asparate double salt compound
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The invention provides a preparation method of an L-ornithine-L-asparate double salt compound. The preparation method includes: 1) dissolving L-ornithine in a proper amount of water, adding L-asparatefor salt forming reaction, adding a proper amount of alkali to neutralize after salt forming reaction is complete so as to obtain a reaction system containing the L-ornithine-L-asparate double salt compound, and cooling, wherein the mole ratio between the L-ornithine and the L-asparate is 1:1; 2) filtering after cooling, adding obtained filtrate into a proper amount of preheated hydrophilic solution, stirring at a constant temperature, cooling, filtering, washing and drying to obtain the L-ornithine-L-asparate double salt compound. The preparation method has few processing steps, the obtainedL-ornithine-L-asparate double salt compound is high in purity and stability and can be sterilized by a terminal excessive killing method, potential medication safety hazards are reduced greatly, andproduction cost is reduced remarkably.
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Paragraph 0047-0050
(2019/10/22)
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- Preparation method of ornithine aspartate
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The invention relates to a preparation method of ornithine aspartate. The preparation method comprises the following steps: adding ammonium carbonate serving as an acid-binding agent into L-ornithine acetate and L-aspartate which serve as original raw materials to neutralize acetate of L-ornithine acetate, so as to obtain free L-ornithine; carrying out a reaction on L-ornithine and L-aspartate to generate salts of L-ornithine and L-aspartate, namely generating ornithine aspartate; and then removing ammonium acetate according to the dissolvability difference between ornithine aspartate and ammonium acetate in a crystallization solvent, and obtaining pure ornithine aspartate. According to the preparation method, ammonium carbonate replaces ammonia water, so that the shortcomings in a preparation process in the prior art are overcome; and the synthesis method is simple in process, safe, environmentally-friendly, high in efficiency, low in cost, high in product purity and convenient for industrial production.
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Paragraph 0030; 0031; 0032; 0033
(2017/07/21)
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