Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies
Thirty-three 4-amino-1,2,4-triazole derivatives 1–33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized via 1H NMR and EI-MS spectroscopic techniques and evaluated for
Reactions between 4-amino-1,2,4-triazole and nitro-substituted benzaldehydes in acetonitrile under neutral conditions afford stable hemiaminals, seven of which have been structurally and spectroscopically characterized. Two Schiff bases have also been obt
Barys, MacIej,Ciunik, Zbigniew,Drabent, Krzysztof,Kwiecien, Anna
experimental part
p. 2605 - 2611
(2011/01/11)
REACTION OF SCHIFF BASES OBTAINED FROM 4-AMINOANTIPYRINE AND 4-AMINO-1,2,4-TRIAZOLE WITH KETONES
With acetophenone and p-nitroacetophenone in alcohol and benzene media in the presence of acid N-arylidene-4-aminoantipyrines form α,β-unsaturated ketones, and with antipyrine the form aryldiantipyrylmethanes.With the same ketones N-arylidene-4-amino-1,2,4-triazoles form the products from addition at the azomethine bond.In both cases reaction with benzylideneacetone was not detected.
Letunov, V. I.
p. 145 - 149
(2007/10/02)
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