- Cascade reaction for the synthesis of polycyclic aromatic hydrocarbons via transient directing group strategy
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A Pd(II)-catalyzed cascade synthesis of diverse polycyclic aromatic hydrocarbons via transient directing group strategy has been developed, involving the consecutive arylation, cyclization and aromatization. The efficiency and practicality were demonstrated by wide substrate range, concise synthetic pathway and mild reaction conditions. The subsequent transformations of the benz[a]anthracene core accessed natural bioactive PAH molecules.
- Wang, Ziqi,Dong, Wendan,Sun, Bing,Yu, Qinqin,Zhang, Fang-Lin
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supporting information
p. 4031 - 4041
(2019/07/03)
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- Reactions of (η6-Arene)tricarbonylchromium Complexes: Hydrogenation, Nitration, and Bromination
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In this study, we explore the reactions of coordinated arenes, e.g., hydrogenation, nitration, and bromination, to prepare compounds which are not accessible from conventional organic synthesis. The reaction products formed from reactions with the coordinated and the uncoordinated arenes are compared. The polycyclic aromatic hydrocarbons (PAHs) employed for this study include phenanthrene, methyl- and acetyl-phenanthrene, and benz[a]anthracene (BA). The tricarbonylchromium group demonstrated various characteristics which influence the reactions in this work, such as an electronic effect to deactivate hydrogenation, a steric effect to exhibit highly positional selective nitration, and a free radical mechanism to direct bromine to attack at the ring coordinated to tricarbonylchromium.
- Own
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p. 417 - 423
(2007/10/03)
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