- Broad spectrum catalytic system for the deep oxidation of toxic organics in aqueous medium using dioxygen as the oxidant
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In water, metallic palladium was found to catalyze the deep oxidation of a wide variety of functional organics by dioxygen at 80-90°C in the presence of carbon monoxide or dihydrogen. Several classes of organic compounds were examined: benzene, phenol and substituted phenols, nitro and halo organics, organophosphorus, and organosulfur compounds. In every case, deep oxidation to carbon monoxide, carbon dioxide, and water occurred in high yields, resulting in up to several hundred turnovers over a 24 h period. For substrates susceptible to hydrogenation, the conversions were generally higher with dihydrogen than with carbon monoxide. For organophosphorus compounds, the system presents the first examples of catalytic cleavage of phosphorus - alkyl bonds.
- Pifer, Anne,Hogan, Terrence,Snedeker, Benjamin,Simpson, Robert,Lin, Minren,Shen, Chengyu,Sen, Ayusman
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- A dimethyl secondary phosphate preparation method and its product and application (by machine translation)
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The invention discloses a method for preparing dimethyl hypophosphite, first, the halogenated methane and methyl dimethyl phosphite according to mol ratio of 0.1-10:100 mixed, 90-150 °C reaction under 4-6h, be dimethyl phosphinic acid methyl ester; and then the the dimethyl phosphinic acid methyl ester mix with deionized water, the 80-120 °C hydrolysis reaction under acidic conditions 6-8h, be dimethyl phosphinic acid; soluble salt of the metal with the dimethyl phosphinic acid mixing, reaction to obtain the precipitate, then post-processed to obtain dimethyl hypophosphite; the metal as Al, Zn, Ti, Ca, mg or Fe. The invention also discloses the method the prepared dimethyl hypophosphite, has higher phosphorus content, will be applied to the engineering plastic, especially in glass fiber reinforced nylon and glass fiber reinforced polyester will obtain better fire retardant effect. (by machine translation)
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Paragraph 0040; 0041
(2017/03/14)
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- Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes
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An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes. The Royal Society of Chemistry.
- Markoulides, Marios S.,Regan, Andrew C.
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p. 119 - 129
(2013/02/23)
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- COMPOSITIONS AND METHODS FOR TREATING CANCER
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The instant invention provides a method of treating a cancer selected from the group consisting of non-small cell lung cancer and breast cancer with an mTOR inhibitor and an αvβ3 integrin antagonist, wherein the mTOR inhibitor is ridaforolimus, everolimus, temsirolimus or a combination thereof.
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- Phosphorus-containing compounds and uses thereof
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This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which:A is absent or is —O—, —S— or —NR2—;Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; 1 K is O or S;each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P;each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; andeach occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H;wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring;each occurrence of G is independently —O—, —S—, —NR2— or (M)X;each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated;each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
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- Phosphorus-containing compounds and uses thereof
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This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA—in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a chemical bond linking a R5 moiety to P; and the other variables are as defined herein.
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- Synthesis of alkyl phosphinic acids from silyl phosphonites and alkyl halides
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Mono- and di-substituted phosphinic acids have been synthesised in a one-pot reaction, by the addition of alkyl halides to silyl phosphonites, under mild and flexible conditions.
- Boyd, E. Andrew,Regan, Andrew C.,James, Keith
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p. 4223 - 4226
(2007/10/02)
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- UEBER EINIGE REAKTIONEN DER DIALKYLBENZYLPHOSPHINIMIDE
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Dialkylbenzylphosphine imides C6H5CH2-PRR'=NR'' (R,R'=CH3, C2H5; R''=H, CH3, Si(CH3)3) react with aliphatic and aromatic aldehydes in benzene solution on heating to 80 deg C directly and in high yields according to a Horner-Wittig-reaction with formation of an olefine whereas ketones like benzophenone and acetophenone only perform an O/NR'' exchange (R''=H).
- Wannagat, Ulrich,Muenstedt, Rainer
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p. 233 - 238
(2007/10/02)
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- Magnetic properties of anhydrous and hydrated dimethylphosphinates of manganese(II). The crystal and molecular structure of poly-bis(μ-dimethylphosphinato)diaquomanganese(II)
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The dimethylphosphinate of manganese(II), Mn2, and its dihydrate have been prepared and studied using magnetic susceptibility, differential scanning calorimetry,and electronic and vibrational spectroscopic methods.The dihydrate was obtained in crystalline form and a single crystal X-ray diffraction study revealed a polymeric structure.Crystals of poly-bis(μ-dimethylphosphinato)diaquomanganese(II) are monoclinic, a = 20.722(3), b = 4.8652(2), c = 11.0689(14) Angstroem, β = 102.209(7) deg, Z = 4, space group C2/c.The structure was solved by conventional heavy-atom methods and was refined by full-matrix least-squares procedures to R = 0.030 and Rw = 0.033 for 983 reflections with I >/= 3?(I).The structure consists of infinite centrosymmetric chains of Mn(II) atoms linked by double phosphinate bridges and extending along the crystallographic b axis.The water molecules are involved in both interchain and bifurcated intrachain hydrogen bonding (O...O = 2.734(2), 2.899(3) and 3.120(3) Angstroem).The coordination about Mn is slightly distorted octahedral with libration-corrected bond lenghts Mn-O(phosphinato) = 2.156(2) and 2.212(2), Mn-OH2 = 2.247(2) Angstroem.Magnetic susceptibility studies on the dihydrate from 300 to 4.2 K reveal a magnetic moment of ca. 5.9 BM over most of the range and give no evidence for significant magnetic exchange.The anhydrous compound, which is considered on the basis of indirect evidence to retain the double phosphinate bridged structure exhibited by the dihydrate, shows relatively strong antiferromagnetic behaviour.The data have been analyzed according to two theoretical models both of which employ the isotropic Heinsenberg Hamiltonian.The scaling model of Wagner and Friedberg gives J = -2.94 cm-1 and g = 2.02 and the interpolation scheme of Weng gives J = -2.69 cm-1 and g = 2.01.The manitude of the exchange coupling is considered in relation to that observed in related manganese compounds and possible reasons for the observed damping of the exchange on hydration are discussed.
- Cicha, Walter V.,Haynes, John S.,Oliver, Katherine W.,Rettig, Steven J.,Thompson, Robert C.,Trotter, James
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p. 1055 - 1062
(2007/10/02)
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- The Acid-catalysed Hydrolysis of O-Methyl Dimethylthiophosphinate. Direct Evidence for Pentaco-ordinate Intermediate Formation in the Conversion of the P=S Ester into the P=O Ester
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Hydrolysis of the title compound in strong acid leads not only to the phosphinic acid but also to methyl dimethylphosphinate which could only be formed by the intermediacy of a pentaco-ordinate species.
- Cook, Robert D.,Metni, Marlene
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p. 832 - 833
(2007/10/02)
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- PHOSPHORIC, PHOSPHONIC, AND PHOSPHINIC ACID AMIDES AS BASES
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Potentiometric titration in nitromethane, IR- and NMR-spectroscopy were used to study the processes of protonation and H-bonding for a number of phosphoric, phosphonic and phosphinic acid amides. 12N)nP(O)R23-n(R1=Me, Et; R2=EtO, Me, Et; n=1-3) including 1,3,2-dioxa-, 1,3,2-oxazaphospholane and phosphorinane derivatives>.It was shown that in these compounds the center of the highest basicity is the oxygen of the phosphoryl group.
- Matrosov, E. I.,Kryuchkov, E. E.,Nifantyev, E. E.,Kozachenko, A. G.,Kabachnik, M. I.
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- PHOSPHINYLALKANOYL PROLINES
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New phosphinylalkanoyl prolines which have the general formula STR1 wherein R 1 is lower alkyl, phenyl or phenyl-lower alkyl; R 2 is hydrogen, phenyl-lower alkyl or a metal ion; R 3 is hydrogen or lower alkyl;R. sub. 4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN IS 0 OR 1,ARE USEFUL AS HYPOTENSIVE AGENTS.
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