- Alkylation-arylation method and application of olefin compound
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The invention discloses an alkyl-arylation method of an olefin compound. The method comprises the following steps: reacting a reaction system comprising a compound a as shown in a formula II, a compound b as shown in a formula III and a compound c as shown in a formula IV to prepare a compound I as shown in a formula I; wherein R1 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl; Ar is selected from one of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R2 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl. The invention further provides application of the method. According to the method provided by the invention, the cheap and easily available catalyst is adopted, the reaction condition is mild, the method is green and environment-friendly, the selectivity and yield of the product are relatively high, a simple and effective method is provided for the field of organic synthesis to obtain the expensive alkyl harmonic diaryl compound, and the method has wide research value and industrial application prospect.
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Paragraph 0169-0171; 0185-0192
(2021/06/22)
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- Cu-Catalyzed Alkylarylation of Vinylarenes with Masked Alkyl Electrophiles
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A Cu-catalyzed synthesis of a range of value-Added 1,1-diarylalkanes by radical alkylarylation of vinylarenes with alkyl peroxides as masked alkyl electrophiles is reported. The reaction features broad substrate scope, good functional group tolerance, and mild reaction conditions. Various bioactive molecules and key pharmaceutical intermediates have been easily synthesized by this method, demonstrating its synthetic value.
- Zhu, Xiaotao,Su, Muqiao,Zhang, Qi,Li, Yajun,Bao, Hongli
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supporting information
p. 620 - 625
(2020/01/02)
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- PROCESS FOR THE PREPARATION OF A FLUSPIRILENE INTERMEDIATE
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The present invention relates to a process for the preparation of a 4,4'- bis(fluorobenzene) derivative, which is an intermediate compound in the synthesis of some drugs, for example in the synthesis of fluspirilene. The invention further relates to new synthetic intermediate compounds.
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- 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
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Novel 3-(1-substituted-4-piperidyl)-1,2-benzisoxazoles, processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.
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