Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides
An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.
Palladium nanoparticles-catalyzed chemoselective hydrogenations, a recyclable system in water
Chemoselective hydrogenation of double bonds in the presence of various functional groups occurred in high yields using water or toluene as solvent, and Pd nanoparticles as catalyst. Up to nine recyclings were achieved in water without decrease of the catalyst activity.
Callis, Nuria Miro,Thiery, Emilie,Le Bras, Jean,Muzart, Jacques
p. 8128 - 8131
(2008/03/13)
Organosoluble copper clusters as precatalysts for carbon - Heteroelement bond-forming reactions: Microwave and conventional heating
(Chemical Equation Presented). The coupling of aryl iodides with alcohols under mild conditions has been explored using self-assembled octanuclear copper clusters as catalysts. Reactions involving tetrahydrofurfuryl alcohol were typically complete in 4-8
Manbeck, Gerald F.,Lipman, Adam J.,Stockland Jr., Robert A.,Freidl, Adrienne L.,Hasler, Amy F.,Stone, Joshua J.,Guzei, Ilia A.
p. 244 - 250
(2007/10/03)
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