- Deoxygenation of sulphoxides to sulphides with trichlorophosphane
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An efficient route to deoxygenation of sulphoxides to sulphides with PCl3 under mild reaction condition was developed. PCl3 was used as a reducing agent for the first time to convert sulphoxides to sulphides. The mild conditions, use of cheap and readily available reagent, and broad substrate scope render it a useful strategy for preparing sulphides.
- Zhao, Xia,Zheng, Xiancai,Yang, Bo,Sheng, Jianqiao,Lu, Kui
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- Synthesis, characterization and antibacterial activity of the thioether linked 1,2,3-triazoles
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A green synthetic approach for the expedite construction of thirty six thioether linked 1,2,3-triazoles was carried out using Cellulose supported CuI nanoparticles in water. The structure of synthesized triazoles was explicated by spectroscopic techniques
- Kaushik, Chander P.,Sangwan, Jyoti
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supporting information
p. 3403 - 3415
(2021/09/13)
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- Synthesis method of thioether compounds
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The invention discloses a synthesis method of thioether compounds. The method comprises steps as follows: phosphorus trichloride and a solvent with uniformly distributed sulfoxide compounds are mixeduniformly, after mixing, the mixture is subjected to a reaction at the temperature of 20-25 DEG C for 0.5-6 h, and the thioether compounds are obtained, wherein the solvent is acetonitrile. Compared with the prior art, the synthesis method has the advantages that raw materials are cheap and easy to obtain, a reducer is cheap and easy to obtain and store, and a series of thioether compounds can beobtained.
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Paragraph 0087-0091
(2019/08/02)
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- Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 1,4-disubstituted 1,2,3-triazoles with ester functionality
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This paper elicits the synthesis of twenty five 1,4-disubstituted 1,2,3-triazole analogs (5a–5y) comprising thioether and ester linkages from aryl(prop-2-yn-1-yl)sulfanes and benzyl 2-azidoacetates employing Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition. Structures of synthesized compounds were elucidated by spectroscopic techniques like FTIR, 1H NMR, 13C NMR, and HRMS. Newly synthesized compounds were screened for in vitro antimalarial evaluation against P. falciparum strain and microbicidal potential against B. subtilis, S. epidermidis, E. coli, P. aeruginosa, C. albicans, and A. niger. Some of synthesized triazoles displayed moderate antimalarial activity against tested strain, while, the compounds 5i and 5n were found to exhibit significant inhibitory activity against most of the tested microbial strains.
- Kaushik,Pahwa, Ashima
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p. 458 - 469
(2017/10/13)
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- Regioselective synthesis and antimicrobial evaluation of some thioether–amide linked 1,4-disubstituted 1,2,3-triazoles
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A series of 1,4-disubstituted 1,2,3-triazoles having thioether as well as amide linkage were synthesized from aryl(prop-2-yn-1-yl)sulfanes and 2-azido-N-substituted acetamides through Cu(I) catalyzed click reaction. Structures of newly synthesized compounds (3a–3x) were confirmed by spectral techniques like FTIR,1H NMR,13C NMR, and HRMS. The synthesized triazoles were evaluated for in vitro antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Candida albicans, and Aspergillus niger. Compounds 3m and 3q displayed appreciable broad spectrum antimicrobial activity against tested microbial strains. The nanoformulations of compounds 3m and 3q were also prepared and examined against one bacterial strain and one fungal strain.
- Kaushik,Pahwa, Ashima,Thakur, Rajesh,Kaur, Pawan
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supporting information
p. 368 - 378
(2017/02/10)
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- Co2(CO)6-propargyl cation mediates glycosylation reaction by using thioglycoside
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We discovered that the cobalt-propargyl cation can mediate the glycosylation reaction by activating the thioglycoside donor. The glyco-oxacarbenium cation was formed by transferring the thio-aglycone to the cobalt-propargyl cation that was generated from the cobalt-propargylated acceptor in situ via the activating with Lewis acid. The reactivity of the donor (Armed or dis-armed) and the amount of the Lewis acid control the releasing rate of the cobalt-propargyl group.
- Xia, Meng-jie,Yao, Wang,Meng, Xiang-bao,Lou, Qing-hua,Li, Zhong-jun
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supporting information
p. 2389 - 2392
(2017/05/29)
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- A Rh-catalyzed 1,2-sulfur migration/aza-Diels-Alder cascade initiated by aza-vinyl carbenoids from sulfur-tethered N-sulfonyl-1,2,3-triazoles
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A novel Rh(ii) catalyzed intramolecular 1,2-sulfur rearrangement/intermolecular aza-Diels-Alder cascade initiated by azavinyl carbenes has been developed, efficiently affording sulfur-containing tetrahydropyridine derivatives or α,β-unsaturated imines wit
- Jiang, Yu,Tang, Xiang-Ying,Shi, Min
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supporting information
p. 2122 - 2125
(2015/02/05)
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- Rh(II)-Catalyzed [2,3]-Sigmatropic Rearrangement of Sulfur Ylides Derived from Cyclopropenes and Sulfides
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(Chemical Equation Presented) A new type of Rh2(OAc)4-catalyzed [2,3]-sigmatropic rearrangement of sulfur ylides is reported. A series of cyclopropenes were successfully employed for [2,3]-sigmatropic rearrangement by a reaction with either allylic or propargylic sulfides. Under the optimized conditions, the reaction afforded the products in moderate to excellent yields. In these transformations, the vinyl metal carbenes generated in situ from the cyclopropenes were effectively trapped by sulfides, resulting in the formation of corresponding products upon [2,3]-sigmatropic rearrangements.
- Zhang, Hang,Wang, Bo,Yi, Heng,Zhang, Yan,Wang, Jianbo
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supporting information
p. 3322 - 3325
(2015/07/15)
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- Investigation of steric and electronic effects in the copper-catalysed asymmetric oxidation of sulfides
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Steric and electronic effects in the copper-catalysed asymmetric oxidation of aryl benzyl, aryl alkyl and alkyl benzyl sulfides have been investigated. The presence of an aryl group directly attached to the sulfur is essential to afford sulfoxides with high enantioselectivities, with up to 97% ee for 2-naphthyl benzyl sulfoxide, the highest enantioselectivity achieved to date for copper-catalysed asymmetric sulfoxidation. In contrast, the benzyl substituent can be replaced by sterically comparable groups with no effect on enantioselectivity. Copper-mediated oxidation of substituted aryl benzyl sulfides display modest steric and electronic effects resulting in comparable or lower enantioselectivities to those obtained with the unsubstituted benzyl phenyl sulfide.
- O'Mahony, Graham E.,Eccles, Kevin S.,Morrison, Robin E.,Ford, Alan,Lawrence, Simon E.,Maguire, Anita R.
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supporting information
p. 10168 - 10184
(2013/11/06)
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- Copper-catalyzed asymmetric oxidation of sulfides
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Copper-catalyzed asymmetric sulfoxidation of aryl benzyl and aryl alkyl sulfides, using aqueous hydrogen peroxide as the oxidant, has been investigated. A relationship between the steric effects of the sulfide substituents and the enantioselectivity of th
- O'Mahony, Graham E.,Ford, Alan,Maguire, Anita R.
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experimental part
p. 3288 - 3296
(2012/05/20)
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- Chemoselective deoxygenation of sulfoxides with titanium tetraiodide
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Chemoselective deoxygenation of sulfoxides was carried out using TiI4 as a reducing agent to give sulfides in good to excellent yields.
- Shimizu,Shibuya,Hayakawa
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p. 1437 - 1438
(2007/10/03)
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- Mass Spectral Rearrangements of 3-Arylsulphonyl-2-arylthiopropenes and N-(4'-Arylsulphonyl-2'-butynyl)-N-(4"-arylthio-2"-butynyl)anilines
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Under electron impact the title compounds undergo skeletal rearrangement in the addition to the anticipated modes of cleavage.The 3-arylsulphonyl-2-arylthiopropenes readily eliminate sulphur dioxide.Other modes of fragmentation include rearrangement to a
- Glaspy, P. E.,Hancock, R. A.,Thyagarajan, B. S.
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p. 281 - 287
(2007/10/02)
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