- Reactions of Tetrasulphur Tetranitride with Alkynes; 1,4,2,6-Dithiadiazines and 1,3,2-Dithiazoles
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Reaction of S4N4 with diphenylacetylene and phenylacetylene gives two new, thermally stable heterocyclic systems, the 1,4,2,6-dithiadiazine (3) and the 1,3,2-dithiazolylimine (7), respectively, as minor products; these structures, determined by X-ray diff
- Daley, Stephen T. A. K.,Rees, Charles W.,Williams, David J.
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- HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS
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The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the
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- Inhibitors of IAP
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The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
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Page/Page column 54-55
(2010/02/15)
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- Reactions of Tetrasulfur Tetranitride with Aryl Dibromomethyl Ketones: One-pot Synthesis of 3-Aroylformamido-4-aryl-1,2,5-thiadiazoles and their Reactions
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Heating of Dibromomethyl aryl ketones with tetrasulfur tetranitride (S4N4) at 115 deg C without a solvent gave 3-aroylformamido-4-aryl-1,2,5-thiadiazoles 8 as major products (12-71percent) and 3,5-diaroyl-1,2,4-thiadiazoles 2 as minor products in certain cases.The structures of compounds 8 were determined based on the X-ray analysis of 3-benzoylformamido-4-phenyl-1,2,5-thiadiazole 8a and comparison with an authentic sample of compound 8a, as well as all the spectroscopic and analytical data of compounds 8.Oxidation of compounds 8 with m-chloroperbenzoic acid in chloroform at room temperature gave compounds 2 (0-66percent), whereas reduction of compounds 8 with sodium boranuide in a mixture of chloroform-ethanol at room temperature gave 3-amino-4-aryl-1,2,5-thiadiazoles 10 (71-93percent).Treatment of 3-(3-nitrobenzoylformamido)-4-(3-nitrophenyl)-1,2,5-thiadiazole 8d with either sodium hydroxide in aqueous p-dioxane at reflux or sodium hydride in chloroform at room temperature gave 3-amino-4-(3-nitrophenyl)-1,2,5-thiadiazole 10d in 56 and 80percent yield, respectively.
- Kim, Kyongtae,Cho, Jaeeock,Yoon, Sung Cheol
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p. 253 - 260
(2007/10/02)
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