A green and highly efficient protocol for catalyst-free Knoevenagel condensation and Michael addition of aromatic aldehydes with 1,3-cyclic diketones in PEG-400
A convenient, highly efficient and green approach for synthesis of tetraketones from aromatic aldehydes with dimedone and 1,3-indanedione at room temperature in PEG-400 is described. The use of PEG-400 as the reaction medium and avoiding the use of any ca
Firouzeh, Nemati,Hossein, Kiani
experimental part
p. 2407 - 2410
(2012/02/04)
Tetraketones: A new class of tyrosinase inhibitors
Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC 50 = 2.61 μM), and 27 (ICsu
Khan, Khalid Mohammed,Maharvi, Ghulam Murtaza,Khan, Mahmud Tareq Hassan,Jabbar Shaikh, Ahson,Perveen, Shahnaz,Begum, Saeedan,Choudhary, Mohammad Iqbal
p. 344 - 351
(2007/10/03)
New Aspects in the Reaction of Azomethines with Cyclic CH-Acidic Compounds
Treatment of substituted benzylidene anilines 1a - f with cyclic CH-acidic compounds 2a - m in ethanol at room temperature yields in addition/elimination reactions the corresponding arylidene derivatives 4 and the 2:1 adducts 5.The addition products 3, which are formed as intermediates, could not be isolated in any case.The donor/acceptor effect of the substituents on the benzylidene moiety influences to a significant extent the reactivity towards the azomethine carbon. Keywords.Azomethine; CH-Acidic compound; Addition/elimination reaction.
Hennig, Lothar,Alva-Astudillo, Mario,Mann, Gerhard,Kappe, Thomas
p. 571 - 580
(2007/10/02)
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