A multicomponent reaction as a versatile tool for the synthesis of spirooxindoles using N-alkylisatins; efficient catalysis by ZnO nanoparticles
An efficient and green protocol for the synthesis of functionalised spirooxindole derivatives is described. This involves the reaction of in situ-generated keto-enaminones with N-alkylisatins in the presence of isothiocyanates.
Reactivities of 3-(1-Azolyl)-2-alken-1-ones and the Related Compounds With Pyrrolidine
From the rate constants of the reaction with pyrrolidine, the reactivities of 3-(1-azolyl)-2-alken-1-ones with nucleophiles were evaluated to be rather high.Especially the reactivities of the quarternary salts of 3-(1-imidazolyl)-2-alken-1-ones were nearly equal to those of 3-chloro-2-alken-1-ones.In conclusion, 3-(1-imidazolyl)-2-alken-1-ones satisfied the practical requirements for the starting materials of the synthesis of 3-hetero-substituted 2-alken-1-ones.